IFIH1: Key Regulator of Immune Response and Potential Drug Target

Target Name: IFIH1

NCBI ID: G64135

IFIH1: Key Regulator of Immune Response and Potential Drug Target

IFIH1 (Inflammasome-associated protein 1) is a protein that is expressed in various tissues throughout the body. It is a key regulator of the immune response and has been implicated in a number of diseases, including inflammation, fibrosis, and autoimmune disorders.

One of the key functions of IFIH1 is its role in the immune response. IFIH1 is involved in the regulation of the production and activation of natural killer cells, which are a critical component of the immune system that help to protect the body against infection and disease. IFIH1 has also been shown to play a role in the regulation of inflammation, as it has been shown to help to dampen the inflammatory response that occurs in response to tissue damage.

In addition to its role in the immune system, IFIH1 has also been implicated in a number of other processes that are important for human health. For example, IFIH1 has been shown to be involved in the regulation of cell death, as it has been shown to help to prevent the apoptosis (programmed cell death) that occurs in damaged cells. IFIH1 has also been shown to play a role in the regulation of cell signaling, as it has been shown to help to regulate the signaling processes that occur between cells.

Despite its many important functions, IFIH1 is still an relatively well-known protein. There is ongoing research into the potential uses of IFIH1 as a drug target, with a number of studies showing that IFIH1 has the potential to be a useful target for the treatment of a variety of diseases, including cancer, autoimmune disorders, and fibrosis.

One of the key advantages of IFIH1 as a drug target is its relatively simple structure. IFIH1 is a small protein that is expressed in a variety of tissues throughout the body, which makes it relatively easy to target with small molecules. This has made IFIH1 an attractive target for the development of new drugs, as it allows researchers to test the effects of a wide range of potential drugs on this protein.

In addition to its relatively simple structure, IFIH1 is also a good candidate for drug targeting because it has a number of unique features that make it interesting as a drug target. For example, IFIH1 is a protein that is involved in a number of different signaling pathways, which makes it a complex target for drugs. This means that it is possible to target IFIH1 with drugs that can inhibit its activity in different ways, which can help to improve the effectiveness of the drug.

Another feature of IFIH1 that makes it an attractive drug target is its role in the regulation of a variety of different processes throughout the body. IFIH1 is involved in the regulation of cell death, cell signaling, and inflammation, which makes it a target that has the potential to have a wide range of effects on a variety of different processes. This means that targeting IFIH1 with drugs could potentially have a beneficial effect on a wide range of different diseases.

In addition to its potential as a drug target, IFIH1 is also a potential biomarker for a variety of different diseases. This is because it is a protein that is expressed in a variety of different tissues throughout the body, which makes it a potential indicator of the health of these tissues. For example, IFIH1 has been shown to be involved in the regulation of the production and activation of natural killer cells, which are a critical component of the immune system. This suggests that IFIH1 may be a useful biomarker for diseases that are characterized by an imbalance in the immune system, such as cancer or autoimmune disorders.

Overall, IFIH1 is an interesting protein that has the potential to be a drug target and a biomarker for a variety of different diseases. Further research is needed to fully understand its role in these processes and to develop new treatments based on its properties.

Protein Name: Interferon Induced With Helicase C Domain 1

Functions: Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines (PubMed:32169843, PubMed:33727702, PubMed:28594402). Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length) (PubMed:22160685). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), and rhinovirus (PubMed:28606988). Detects coronavirus SARS-CoV-2 (PubMed:33440148, PubMed:33514628). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines

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