IFT57: Protein-Protein Transport and Mitochondrial Enzyme Transport

Target Name: IFT57

NCBI ID: G55081

IFT57: Protein-Protein Transport and Mitochondrial Enzyme Transport

IFT57, also known as intraflagellar transport 57, is a protein that plays a crucial role in the transport of organelles within cells. It is a member of the transport proteins family 18 (TF-18), which are known for their ability to transport various organelles, including mitochondrial enzymes, to their sites of action. IFT57 is expressed in most tissues and cells, and its function has been extensively studied.

IFT57 is a 21-kDa protein that consists of 115 amino acid residues. It has a characteristic Rossmann-fold structure that is typical of proteins involved in protein-protein interactions. The Rossmann-fold is a conserved structural motif that is found in many proteins that play a structural role in protein-protein interactions, such as the interaction between the amino acids that make up the protein.

IFT57 functions as a protein-protein transport protein. It has been shown to transport a variety of organelles to their sites of action, including mitochondrial enzymes, ribosomes, and the endoplasmic reticulum (ER). IFT57 has been shown to play a role in the transport of mitochondrial enzymes to the mitochondrial cytoplasm, where they can be involved in various cellular processes, including energy metabolism and cellular signaling pathways.

IFT57 has also been shown to be involved in the transport of ribosomes to the endoplasmic reticulum, where they can be involved in protein synthesis. IFT57 has been shown to interact with the protein p16, which is involved in the regulation of ribosome activity. This interaction between IFT57 and p16 suggests that IFT57 may be involved in the regulation of ribosome activity, including the rate at which new ribosomes are added to the endoplasmic reticulum.

IFT57 has also been shown to be involved in the transport of various endoplasmic reticulum-associated proteins (ERAs) to their sites of action. EHRAs are proteins that are involved in various cellular processes, including protein synthesis, signaling, and cell adhesion. IFT57 has been shown to interact with the protein TRPV4, which is involved in the regulation of intracellular temperature and the levels of various ions in the ER. This interaction between IFT57 and TRPV4 suggests that IFT57 may be involved in the regulation of ERAs, including the levels of temperature and ion in the ER.

In addition to its role in protein-protein transport, IFT57 has also been shown to play a role in the regulation of cellular processes. For example, IFT57 has been shown to be involved in the regulation of mitochondrial fusion, a process that is critical for the production of energy in the cell. IFT57 has been shown to interact with the protein mitofusin, which is involved in the regulation of mitochondrial fusion. This interaction between IFT57 and mitofusin suggests that IFT57 may be involved in the regulation of mitochondrial fusion, a critical process for the production of energy in the cell.

IFT57 has also been shown to be involved in the regulation of cellular signaling pathways. For example, IFT57 has been shown to be involved in the regulation of the TGF-β pathway, a pathway that is involved in cell growth, differentiation, and survival. IFT57 has been shown to interact with the protein FGF1, which is involved in the regulation of TGF-β pathway. This interaction between IFT57 and FGF1 suggests that IFT57 may be involved in the regulation of TGF-

Protein Name: Intraflagellar Transport 57

Functions: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear

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