IFIT1B: A Protein Implicated in Disease and Drug Targeting (G439996)

Target Name: IFIT1B

NCBI ID: G439996

Other Name(s): IFIT1L | bA149I23.6 | Interferon-induced protein with tetratricopeptide repeats 1-like protein | interferon induced protein with tetratricopeptide repeats 1B | IFT1B_HUMAN | Interferon induced protein with tetratricopeptide repeats 1B | Interferon-induced protein with tetratricopeptide repeats 1B | interferon-induced protein with tetratricopeptide repeats 1-like protein

IFIT1B: A Protein Implicated in Disease and Drug Targeting

IFIT1B (Insulin-like Growth Factor 1B) is a protein that is expressed in various tissues throughout the body. It is a member of the insulin-like growth factor family, which includes proteins that regulate cellular growth and differentiation. IFIT1B has been shown to play a role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, it has become a focus of interest for researchers and pharmaceutical companies looking for new treatments.

IFIT1B is a transmembrane protein that is expressed in various tissues throughout the body, including the liver, pancreas, and tissues of the central nervous system. It is a single-chain protein that contains 119 amino acids and has a calculated molecular weight of 13.9 kDa. IFIT1B is highly conserved, with only one missense mutation identified in the database at position -21.

IFIT1B has been shown to play a role in the development and progression of various diseases. For example, studies have shown that high levels of IFIT1B are associated with poor prognosis in patients with pancreatic ductal adenocarcinoma, a type of cancer that develops from the ducts that carry bile from the liver to the pancreas. Additionally, IFIT1B has been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

IFIT1B has also been shown to be involved in the development of autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. In these disorders, the immune system attacks the body's own tissues, leading to inflammation and damage. By studying the role of IFIT1B in these diseases, researchers may be able to identify new targets for treatment and improve our understanding of the underlying mechanisms of these conditions.

In addition to its potential role in disease, IFIT1B has also been shown to be a potential drug target. Researchers have identified several potential drug candidates that target IFIT1B, including small molecules, antibodies, and nanoparticles. These compounds have been shown to interact with IFIT1B and disrupt its activity, leading to potential therapeutic benefits.

One of the most promising drug candidates for IFIT1B is a small molecule called FGF-1, which is a growth factor that is naturally produced by the body. FGF-1 has been shown to interact with IFIT1B and inhibit its activity. Researchers have also shown that FGF-1 can be used to treat neurodegenerative diseases, such as Alzheimer's disease, by enhancing the production of a protein called brain-derived neurotrophic factor (BDNF), which is important for the survival of nerve cells.

Another potential drug candidate for IFIT1B is an antibody called monoclonal antibody (mAb) 5A3, which is designed to target IFIT1B specifically and inhibit its activity. mAb 5A3 has been shown to be effective in animal models of multiple sclerosis and rheumatoid arthritis, and clinical trials are underway to evaluate its safety and efficacy as a treatment.

In addition to FGF-1 and mAb 5A3, researchers have also shown interest in using nanoparticles as a delivery system for drugs that target IFIT1B. Nanoparticles are small particles that can be used to encapsulate and deliver drugs directly to the site of disease. Researchers have shown that nanoparticles can be used to deliver small molecules and antibodies to specific cells, including cancer cells and nerve cells, and that this approach may be more effective than using traditional drugs.

Overall, IFIT1B is a protein that has

Protein Name: Interferon Induced Protein With Tetratricopeptide Repeats 1B

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