IFIT2: Key Regulator of Immune Response and Disease (G3433)

Target Name: IFIT2

NCBI ID: G3433

IFIT2: Key Regulator of Immune Response and Disease

IFIT2 (IFI54), also known as interleukin-54, is a protein that is expressed in various tissues throughout the body. It is a key regulator of immune responses and has been implicated in a number of diseases, including cancer, autoimmune disorders, and obesity.

IFIT2 is a member of the IFIT family, which is characterized by the presence of a nucleotide-binding oligomerization domain (NOD) and a carboxy-terminal hypervariable region (CTHR). NODs are known for their ability to form a covalent complex with nucleotides, while CTHRs are involved in the regulation of protein stability and interactions.

IFIT2 is a 21-kDa protein that is expressed in a variety of tissues, including bone marrow, spleen, skin, and various organs. It is highly expressed in tissues that are highly susceptible to infection, such as the gut and the respiratory tract, and is also expressed in tissues that are less susceptible, such as the skin and the liver.

IFIT2 has been shown to play a key role in the regulation of immune responses and in the development of autoimmune disorders. It is a negative regulator of the T-cell receptor (TCR), which is responsible for cell survival and proliferation. In addition, IFIT2 has been shown to regulate the activity of natural killer cells (NK cells), which are important for immune surveillance and elimination of infected or abnormal cells.

IFIT2 has also been shown to be involved in the regulation of cellular signaling pathways that are important for cancer development. For example, it has been shown to regulate the activity of the oncogene transforming growth factor-beta (TGF-beta), which is a key regulator of cell proliferation and transformation. In addition, IFIT2 has been shown to interact with the tumor suppressor protein p53, which is important for the regulation of DNA damage repair and cell cycle progression.

IFIT2 has also been shown to be involved in the regulation of obesity and other metabolic disorders. For example, it has been shown to regulate the activity of the adiponectin receptor, which is responsible for the regulation of fat metabolism. In addition, IFIT2 has been shown to interact with the protein SREBP-2, which is involved in the regulation of lipid metabolism and the development of obesity.

IFIT2 is a potential drug target for a variety of diseases, including cancer, autoimmune disorders, and obesity. For example, it has been shown to be a good candidate for targeting with small molecules, including inhibitors of the TGF-beta pathway and inhibitors of SREBP-2. In addition, IFIT2 may also be a good candidate for targeting with antibodies that are specific for its NOD and CTHR domains.

Overall, IFIT2 is a protein that has important roles in the regulation of immune responses, cancer development, and obesity. It is a potential drug target for a variety of diseases and may be a useful biomarker for the diagnosis and treatment of these diseases. Further research is needed to fully understand the role of IFIT2 in these processes and to develop effective treatments.

Protein Name: Interferon Induced Protein With Tetratricopeptide Repeats 2

Functions: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis

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