IFNB1: The Potential Drug Target and Biomarker (G3456)

Target Name: IFNB1

NCBI ID: G3456

IFNB1: The Potential Drug Target and Biomarker

Interferon-beta (IFNB) is a protein that plays a crucial role in the immune response and inflammation regulation. It is a member of the interferon family, which includes proteins that regulate various cellular processes, including cell growth, differentiation, and inflammation. One of the subtypes of IFNB is IFNB1, which is a protein that has been identified as a potential drug target and biomarker for various diseases.

IFNB1 is involved in the regulation of immune responses, including the regulation of T cells, B cells, and natural killer cells. It is expressed in various tissues and cells throughout the body, including the spleen, lymph nodes, thymus, spleen cells, and blood vessels. IFNB1 has been shown to play a role in the regulation of inflammation and inflammation-related diseases.

One of the potential drug targets for IFNB1 is the treatment of autoimmune diseases, such as rheumatoid arthritis (RA), lupus, and multiple sclerosis. These diseases involve an overactive immune response that can cause chronic inflammation and damage to various body parts. IFNB1 has been shown to be involved in the regulation of the immune response, and targeting it may be a promising approach to treating autoimmune diseases.

Another potential drug target for IFNB1 is the treatment of cancer.IFNB1 has been shown to play a role in the regulation of cell growth and differentiation, which can be a potential mechanism for the development and progression of cancer. Therefore, targeting IFNB1 with drugs that can inhibit its activity may be a promising approach to cancer treatment.

IFNB1 has also been shown to be involved in the regulation of inflammation-related diseases, including inflammation caused by bacterial and viral infections.IFNB1 has been shown to play a role in the regulation of the innate immune response, which is the body's first line of defense against infection. Therefore, targeting IFNB1 with drugs that can inhibit its activity may be a promising approach to treating bacterial and viral infections.

In addition to its potential drug targets, IFNB1 is also a potential biomarker for various diseases.IFNB1 is a protein that can be easily purified and characterized, making it an attractive candidate for use as a biomarker.IFNB1 has been shown to be involved in the regulation of various immune responses, including the regulation of T cells, B cells, and natural killer cells. Therefore, measuring the levels of IFNB1 in various tissues and cells may be a useful diagnostic tool for evaluating the severity of immune-related diseases.

IFNB1 has also been shown to be involved in the regulation of inflammation.IFNB1 has been shown to play a role in the regulation of the inflammatory response, including the regulation of inflammation caused by bacterial and viral infections. Therefore, measuring the levels of IFNB1 in various tissues and cells may be a useful biomarker for evaluating the severity of inflammatory diseases.

In conclusion, IFNB1 is a protein that has been shown to play a role in the regulation of various immune responses and diseases.IFNB1 may be a potential drug target and biomarker for various diseases, including autoimmune diseases, cancer, and inflammatory diseases. Further research is needed to fully understand the role of IFNB1 in the immune response and to develop effective treatments for these diseases.

Protein Name: Interferon Beta 1

Functions: Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli (PubMed:6157094, PubMed:6171735, PubMed:8027027, PubMed:7665574, PubMed:8969169, PubMed:10049744, PubMed:10556041). Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (PubMed:8027027, PubMed:7665574, PubMed:8969169, PubMed:10049744, PubMed:10556041). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (By similarity). Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor (By similarity). Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss (By similarity). IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity)

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