IER3: A Protein Involved in Cellular Processes That Affect Cell Survival and Proliferation

Target Name: IER3

NCBI ID: G8870

IER3: A Protein Involved in Cellular Processes That Affect Cell Survival and Proliferation

IER3 (IEX-1L) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the IEX family of transmembrane proteins, which are characterized by their ability to form a continuous transmembrane region that is involved in various signaling pathways.

One of the most significant functions of IER3 is its role in the regulation of ion channels, which are responsible for the flow of electrical current through the cell membrane. IER3 is involved in the regulation of the delayed rectifier channels, which are important for the maintenance of the resting membrane potential of the heart.

In addition to its role in ion channel regulation, IER3 is also involved in the regulation of various signaling pathways that are involved in cell growth, differentiation, and survival. For example, IER3 has been shown to be involved in the regulation of the TGF-β pathway, which is involved in the development and maintenance of tissues such as muscles, bones, and organs.

IER3 is also involved in the regulation of the Wnt pathway, which is involved in the development and maintenance of tissues that are involved in the development of cancers. The Wnt pathway is a critical regulator of cell growth and differentiation, and IER3 is shown to be involved in the regulation of its activity.

In addition to its involvement in ion channel and signaling pathway regulation, IER3 is also involved in the regulation of various cellular processes that are important for cell survival. For example, IER3 is involved in the regulation of cell adhesion, which is important for the maintenance of tissue structure and function.

IER3 is also involved in the regulation of cellular signaling pathways that are important for cell survival and proliferation. For example, IER3 has been shown to be involved in the regulation of the PI3K/AKT signaling pathway, which is involved in the production of signaling molecules that are important for the survival and proliferation of cells.

In conclusion, IER3 is a protein that is involved in a wide range of cellular processes that are important for cell survival and proliferation. Its role in the regulation of ion channels, signaling pathways, and cellular processes that are important for cell survival and proliferation makes IER3 an attractive potential drug target. Further research is needed to fully understand the role of IER3 in these processes and to develop effective therapies that target this protein.

Protein Name: Immediate Early Response 3

Functions: May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment

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