TMEM202: A Transmembrane Protein Target for Drug Development and Cancer Treatment

Target Name: TMEM202

NCBI ID: G338949

Other Name(s): Transmembrane protein 202, transcript variant 1 | Transmembrane protein 202 | TMEM202 variant 1 | transmembrane protein 202 | TM202_HUMAN

TMEM202: A Transmembrane Protein Target for Drug Development and Cancer Treatment

TMEM202 (Transmembrane protein 202, transcript variant 1) is a gene that encodes a protein involved in various cellular processes, including cell signaling, neurotransmission, and intracellular signaling. The protein is expressed in most tissues and cells of the body, making it an attractive candidate for drug targeting and research into cellular mechanisms.

Recent studies have identified TMEM202 as a potential drug target for various diseases, including cancer. Its unique structure and various functions make it an interesting target for small molecules, antibodies, or other therapeutic agents. In this article, we will explore the biology and potential applications of TMEM202, with a focus on its potential as a drug target and its relevance in cancer treatment.

Structure and Function

TMEM202 is a transmembrane protein that is involved in various signaling pathways. It is a member of the subfamily of transmembrane protein 2 (TMEM), which includes other well-known proteins such as TMEM180, TMEM181, and TMEM183. TMEM202 is characterized by a long extracellular domain, a transmembrane region, and an intracellular domain.

The transmembrane region of TMEM202 is rich in various charged and polar amino acids, such as Asp, Glu, and Lys. These features make the protein susceptible to various signaling interactions, including tyrosination, phosphorylation, and interactions with small molecules or other transmembrane proteins. Additionally, the intracellular domain of TMEM202 contains several positively charged amino acids, including Asp, which can interact with various intracellular signaling molecules.

TMEM202 is involved in various cellular processes, including cell signaling, neurotransmission, and intracellular signaling. It plays a role in the regulation of protein kinase (PKG) signaling, which is a widely-studied signaling pathway that is involved in various cellular processes, including cell growth, differentiation, and survival. TMEM202 is also involved in the regulation of ion channels, including the Na+/K+-ATPase (Na+/K+-ATPase), which is responsible for maintaining the resting membrane potential of many cell types.

TMEM202 has also been shown to play a role in neurotransmission, specifically in the regulation of synaptic plasticity and learning. Its involvement in these processes makes it an attractive candidate for the development of drugs that target neurotransmitter systems and improve cognitive function.

Drug Sensitivity and Targetability

TMEM202 has been identified as a potential drug target due to its unique structure and various functions. Its transmembrane region and intracellular domain make it susceptible to various signaling interactions, including tyrosination, phosphorylation, and interactions with small molecules or other transmembrane proteins. Additionally, its positively charged amino acids make it susceptible to ion interactions, which can modulate its activity.

Recent studies have shown that TMEM202 is a robust target for small molecules, including inhibitors of tyrosination and inhibitors of protein-protein interactions. These studies have led to the identification of potential drug candidates that can modulate TMEM202 activity and improve cellular processes, including neurotransmission and protein kinase signaling.

TMEM202 has also been shown to be a potential cancer drug target. Its involvement in various signaling pathways makes it an attractive candidate for the development of anti-cancer drugs. The identification of TMEM202 as a cancer drug target has led to the development of various compounds that can modulate its activity and inhibit its functions in cancer cells.

Potential Therapeutic Applications

The identification of TMEM202 as a potential drug target has led to the development of various therapeutic compounds that can modulate its activity. These compounds can be used to treat various diseases, including cancer.

1. Cancer Treatment: TMEM202 has

Protein Name: Transmembrane Protein 202

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