Targeting JMJD8: A Potential Drug and Biomarker for Many Diseases

Target Name: JMJD8

NCBI ID: G339123

Targeting JMJD8: A Potential Drug and Biomarker for Many Diseases

JMJD8, also known as JMJD8-HUMAN, is a protein that is expressed in various tissues of the human body. It is a key regulator of the Integrin alpha-2 (ITGA2) receptor, which is involved in many cellular processes in the body, including cell adhesion, migration, and invasion.

The ITGA2 receptor is a transmembrane protein that is composed of an extracellular portion and an intracellular portion. The extracellular portion of the ITGA2 receptor is involved in cell adhesion and migration, while the intracellular portion is involved in the regulation of cellular processes such as cell cycle progression and apoptosis.

JMJD8 is a 21-kDa protein that is expressed in various tissues of the human body, including the liver, lung, heart, kidney, and pancreas. It is highly expressed in the liver, with lower levels of expression in the pancreas and other tissues.

JMJD8 is involved in the regulation of ITGA2 receptor function. It has been shown to interact with the ITGA2 receptor and to regulate its activity. JMJD8 has been shown to play a role in the regulation of cell adhesion and migration, as well as in the regulation of cellular processes such as cell cycle progression and apoptosis.

In addition to its role in regulating ITGA2 receptor function, JMJD8 is also involved in the regulation of many other cellular processes in the body. It is a regulator of the T-cell receptor (TCR), which is involved in the regulation of cellular immune responses. It is also involved in the regulation of the production of platelet-derived growth factors (PDGFs), which are important for cellular signaling and growth.

JMJD8 is a potential drug target for the treatment of many diseases. Its regulation of ITGA2 receptor function and its involvement in the regulation of cellular processes that are involved in many diseases make it an attractive target for intervention.

One approach to targeting JMJD8 is to use small molecules that can modulate its activity. Such molecules can be identified through a variety of techniques, including high-throughput screening and bioinformatics analysis.

Another approach to targeting JMJD8 is to use antibodies that can specifically recognize and target it. These antibodies can be used to treat diseases in which JMJD8 is hyper expressed or underexpressed, such as cancer, neurodegenerative diseases, and autoimmune diseases.

JMJD8 is also a potential biomarker for the diagnosis and monitoring of many diseases. Its regulation of ITGA2 receptor function and its involvement in the regulation of cellular processes that are involved in many diseases make it an attractive candidate for use as a diagnostic or monitoring tool.

In conclusion, JMJD8 is a protein that is involved in the regulation of many cellular processes in the body. Its regulation of ITGA2 receptor function and its involvement in the regulation of cellular processes that are involved in many diseases make it an attractive target for intervention. The development of small molecules and antibodies that can modulate its activity may lead to the development of new treatments for a variety of diseases. Additionally, its potential as a biomarker for the diagnosis and monitoring of many diseases makes it an important molecule to study further.

Protein Name: Jumonji Domain Containing 8

Functions: Functions as a positive regulator of TNF-induced NF-kappa-B signaling (PubMed:27671354). Regulates angiogenesis and cellular metabolism through interaction with PKM (PubMed:27199445)

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