WDR86: A Potential Drug Target and Biomarker (G349136)

Target Name: WDR86

NCBI ID: G349136

WDR86: A Potential Drug Target and Biomarker

Introduction

WDR86 is a protein that is expressed in various tissues and cells throughout the body. It is a member of the WD repeat-containing protein 86 family, which is a subgroup of the protein family known as the K-type ATPases. WDR86 is unique due to its potential role as a drug target and biomarker.

The WD Repeat-Containing Protein 86 Family

The WD repeat-containing protein 86 family is a subgroup of the K-type ATPases, which are a diverse family of transmembrane proteins that play a key role in cellular signaling. These proteins are characterized by the presence of a K-loop, a conserved motif that is involved in the transfer of ATP energy to the protein.

WDR86 is a member of the WD repeat-containing protein 86 family, which is characterized by the presence of a WD domain and a unique N-terminus. The WD domain is a conserved region that is involved in the transfer of ATP energy, while the N-terminus is responsible for the protein's intracellular localization and stability.

WDR86's Potential Role as a Drug Target

WDR86 has been identified as a potential drug target due to its unique structure and its involvement in cellular signaling. The WD domain is known for its ability to transfer ATP energy to other molecules, making it an attractive target for small molecules that can inhibit this function . Additionally, the WD domain is also known to be involved in the regulation of cellular signaling, which further increases its potential as a drug target.

WDR86 has been shown to play a role in a variety of cellular processes, including cell signaling, cell division, and tissue growth. It has also been shown to interact with a variety of molecules, including tyrosine kinases, G-protein-coupled receptors, andion channels.

WDR86 has been identified as a potential drug target by several studies. For example, researchers have shown that inhibitors of the WD domain can inhibit the activity of severalty tyrosine kinases, including FAK, PDGFR-尾, and Src. Additionally, they have shown that Inhibitors of WDR86 can inhibit the migration and invasion of cancer cells.

WDR86's Potential as a Biomarker

WDR86 has also been identified as a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. The ability of WDR86 to interact with a variety of molecules, including tyrosine kinases, G-protein-coupled receptors, and ion channels makes it an attractive candidate for use as a biomarker.

In cancer, WDR86 has been shown to be involved in the regulation of cell signaling, including the regulation of cell growth, apoptosis, and angiogenesis. Additionally, studies have shown that WDR86 is involved in the development and progression of neurodegenerative diseases, including Alzheimer's disease. and Parkinson's disease.

In cardiovascular diseases, WDR86 has been shown to be involved in the regulation of cell signaling, including the regulation of blood pressure and heart rate. This makes it an attractive candidate for use as a biomarker for cardiovascular disease.

Conclusion

In conclusion, WDR86 is a protein that has the potential to be a drug target and biomarker. Its unique structure and its involvement in cellular signaling make it an attractive candidate for both drug development and biomarker research. Further studies are needed to fully understand the role of WDR86 in cellular signaling and its potential as a drug target and biomarker.

Protein Name: WD Repeat Domain 86

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