Target Name: WLS
NCBI ID: G79971
Other Name(s): mig-14 | G protein-coupled receptor 177 | MRP | wntless Wnt ligand secretion mediator | Integral membrane protein GPR177 | Protein wntless homolog | integral membrane protein GPR177 | Wnt ligand secretion mediator, transcript variant 2 | GPR177 | WLS_HUMAN | Protein wntless homolog (isoform 2) | putative NF-kappa-B-activating protein 373 | WLS variant 2 | Protein evenness interrupted homolog | protein evenness interrupted homolog | Putative NF-kappa-B-activating protein 373 | Putative NFkB activating protein 373 | FLJ23091 | putative NFkB activating protein 373 | EVI | Wnt ligand secretion mediator | C1orf139 | ZKS

Understanding The Role of WLS in Cancer and Pain

WLS (Wing-Length Scale), also known as mig-14, is a protein that is expressed in the wing muscles of flies. It is a key regulator of fly growth and development, and has been implicated in a number of biological processes.

One of the most interesting aspects of WLS is its role in the development and progression of cancer. Several studies have shown that WLS is highly expressed in a variety of cancer types, including breast, lung, and ovarian cancer. Additionally, research has suggested that high levels of WLS may be a risk factor for cancer progression.

Another potential drug target for WLS is its role in the regulation of pain and inflammation. Several studies have shown that WLS is involved in the regulation of pain sensitivity, and is also involved in the production of inflammatory cytokines. This suggests that WLS may be a useful target for the development of pain and inflammation therapies.

In addition to its potential as a drug target, WLS is also a potential biomarker for a variety of diseases. Its expression has been shown in a variety of tissues and biological processes, including the brain, the eye, and the immune system. This suggests that it may be a useful tool for the diagnosis and treatment of a wide range of diseases.

Overall, WLS is a protein that is widely expressed in a variety of tissues and biological processes, and has been implicated in a number of important biological processes. Further research is needed to fully understand its role in disease and to develop effective treatments.

Protein Name: Wnt Ligand Secretion Mediator

Functions: Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins (PubMed:34587386). Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity)

More Common Targets

WNK1 | WNK2 | WNK3 | WNK4 | Wnt | WNT1 | WNT10A | WNT10B | WNT11 | WNT16 | WNT2 | WNT2B | WNT3 | WNT3A | WNT4 | WNT5A | WNT5B | WNT6 | WNT7A | WNT7B | WNT8A | WNT8B | WNT9A | WNT9B | WRAP53 | WRAP73 | WRN | WRNIP1 | WSB1 | WSB2 | WSCD1 | WSCD2 | WSPAR | WT1 | WT1-AS | WTAP | WTAPP1 | WTIP | WWC1 | WWC2 | WWC2-AS2 | WWC3 | WWOX | WWP1 | WWP2 | WWTR1 | WWTR1-AS1 | XAB2 | XACT | XAF1 | XAGE-4 | XAGE1A | XAGE1B | XAGE1D | XAGE2 | XAGE3 | XAGE5 | XBP1 | XCL1 | XCL2 | XCR1 | XDH | XG | XGY2 | XIAP | XIRP1 | XIRP2 | XIST | XK | XKR3 | XKR4 | XKR5 | XKR6 | XKR7 | XKR8 | XKR9 | XKRX | XKRY | XKRYP7 | XLOC_007697 | XLOC_008559 | XLOC_009911 | XNDC1N | XPA | XPC | XPC complex | XPNPEP1 | XPNPEP2 | XPNPEP3 | XPO1 | XPO4 | XPO5 | XPO6 | XPO7 | XPOT | XPR1 | XRCC1 | XRCC2 | XRCC3 | XRCC4