LCN1: A GPCR-Coupled Receptor Protein with Potential as A Drug Target

Target Name: LCN1

NCBI ID: G3933

LCN1: A GPCR-Coupled Receptor Protein with Potential as A Drug Target

LCN1 (Lipocalin 1-like 2) is a protein that is expressed in various tissues throughout the body, including the brain, heart, liver, and kidneys. It is a member of the G-protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play a crucial role in cellular signaling.

LCN1 is characterized by its ability to interact with several different GPCR ligands, including G伪11, G伪13, and G伪16. These interactions allow LCN1 to modulate various cellular processes, including cell adhesion, migration, and survival.

One of the unique features of LCN1 is its ability to form a complex with the protein FERMT1 (F-actinin-related protein T1), which is a key regulator of cell-cell adhesion. This complex formation allows LCN1 to physically interact with FERMT1 and regulate its activity, which in turn can influence the strength and stability of cell-cell bonds.

LCN1 has also been shown to play a role in the regulation of cellular migration and the maintenance of tissue structure. It has been shown to promote the migration of various cell types, including cancer cells, and to contribute to the formation of scar tissue in wound healing.

In addition to its role in cellular signaling, LCN1 has also been shown to have potential as a drug target. Several studies have suggested that LCN1 may be a potential target for small molecules, including inhibitors of G伪11 or G伪13 function, which would modulate LCN1's activity and potentially have therapeutic applications.

One of the challenges in studying LCN1 as a drug target is its complex structure and the difficulty of modulating its activity without disrupting its natural function. However, these challenges are being addressed by ongoing research and the development of new technologies, such as RNA-based assays and high-throughput screening arrays, which are allowing researchers to study LCN1 more fully and to identify potential drug targets.

In conclusion, LCN1 is a unique and important protein that has the potential to be a drug target. Its ability to interact with multiple GPCR ligands and its role in cellular signaling make it an attractive target for small molecules. As research continues to advance, it is likely that LCN1 will become a valuable tool for the development of new therapeutic approaches.

Protein Name: Lipocalin 1

Functions: Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket

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