TMEM200B: A Transmembrane Protein Extracted from the Human Brain for Potential Therapeutic Applications

Target Name: TMEM200B

NCBI ID: G399474

TMEM200B: A Transmembrane Protein Extracted from the Human Brain for Potential Therapeutic Applications

TMEM200B, also known as transmembrane protein 200B, is a protein that is expressed in the brain and has been shown to play a critical role in various physiological processes. The protein is localized to the endoplasmic reticulum and secreted to the cell surface, where it functions in various cellular processes, including cell signaling, neurotransmitter release, and intracellular signaling.

Recent studies have suggested that TMEM200B may have potential as a drug target or biomarker. In this article, we will explore the biology and potential applications of TMEM200B in more detail.

Biochemistry and Localization

TMEM200B is a transmembrane protein that is composed of 158 amino acids. The protein has a calculated molecular mass of 19.1 kDa and a calculated pI of 4.8. TMEM200B is expressed in the brain and other tissues, including the heart, pancreas, and gastrointestinal tract. The protein is primarily localized to the endoplasmic reticulum and is considered as a secreted protein.

Function

TMEM200B is involved in various cellular processes, including cell signaling, neurotransmitter release, and intracellular signaling. The protein has been shown to play a critical role in the regulation of neurotransmitter release from nerve axons. TMEM200B is also involved in the regulation of intracellular signaling, including the production of reactive oxygen species (ROS) and the detoxification of oxidative stress.

In addition, TMEM200B has been shown to play a critical role in the development and maintenance of the blood-brain barrier. The protein is involved in the regulation of the outflow of neurons from the nervous system, which is critical for the formation and maintenance of the blood-brain barrier.

Potential Applications

TMEM200B has been suggested as a potential drug target or biomarker due to its unique function in various cellular processes. The protein is involved in the regulation of neurotransmitter release, which could make it a useful target for drugs that target neurotransmitter release. Additionally, TMEM200B is involved in the regulation of intracellular signaling, which could make it a useful target for drugs that target intracellular signaling pathways.

TMEM200B may also have potential as a biomarker for various neurological disorders, including Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders. The protein is expressed in the brain and has been shown to play a critical role in the development and progression of these disorders.

Conclusion

TMEM200B is a transmembrane protein that is expressed in the brain and has been shown to play a critical role in various physiological processes. The protein has a potential as a drug target or biomarker, and further studies are needed to fully understand its function and potential applications in human disease.

Protein Name: Transmembrane Protein 200B

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