SMAD2: A Non-Coding RNA Protein Involved in Gene Regulation and DNA Damage Repair

Target Name: SMAD2

NCBI ID: G4087

SMAD2: A Non-Coding RNA Protein Involved in Gene Regulation and DNA Damage Repair

SMAD2 (SMAD2 gene) is a gene that encodes a protein known as SMAD2 (small molecule-activated DNA binding protein 2). SMAD2 is a non-coding RNA molecule that plays a critical role in gene regulation and DNA damage repair. It is a key player in the DNA damage response, which is a set of cellular pathways that respond to DNA damage and ensure the integrity of the genetic material.

SMAD2 is a protein that is expressed in many different tissues and cells throughout the body. It is highly conserved, with similar sequences across different species. SMAD2 is typically expressed in the cytoplasm of eukaryotic cells and has been shown to be involved in various cellular processes, including cell growth, differentiation, and stress response.

One of the unique features of SMAD2 is its ability to interact with DNA. It has been shown to form a complex with DNA in a process known as DNA-SMAD2 interaction, which is critical for its function. This interaction allows SMAD2 to access and modify the DNA, which is necessary for the regulation of gene expression and DNA damage repair.

SMAD2 is also involved in the repair of DNA damage caused by various types of stressors, such as UV radiation, chemical agents, and radiation. It has been shown to play a key role in the repair of DNA double-strand breaks, which are the most common type of DNA damage.

In addition to its role in DNA damage repair, SMAD2 is also involved in the regulation of gene expression. It has been shown to interact with various transcription factors, including DNA-protein binding proteins and RNA-protein binding proteins. This interaction allows SMAD2 to regulate the activity of these transcription factors and ultimately control the expression of target genes.

SMAD2 is also involved in the regulation of cellular signaling pathways. It has been shown to play a role in the signaling pathway known as the TOR signaling pathway. This pathway is involved in cell growth, stress response, and repair, and is a key regulator of cellular processes that are critical for the survival of cells.

SMAD2 is a potential drug target and has been shown to have a variety of therapeutic potential. For example, it has been shown to be involved in the regulation of cell death, and may be a useful target for therapies that are designed to extend the lifespan of cells. Additionally, SMAD2 has been shown to be involved in the regulation of cellular signaling pathways, and may be a useful target for therapies that are designed to modulate cellular signaling pathways.

In conclusion, SMAD2 is a non-coding RNA molecule that is involved in a variety of cellular processes, including gene regulation and DNA damage repair. It is a key player in the DNA damage response and has been shown to have a variety of therapeutic potential. Further research is needed to fully understand the role of SMAD2 in gene regulation and to develop effective therapies based on this protein.

Protein Name: SMAD Family Member 2

Functions: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator

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