MZT1: A Potential Drug Target and Biomarker for Cancer (G440145)

Target Name: MZT1

NCBI ID: G440145

MZT1: A Potential Drug Target and Biomarker for Cancer

Mitotic-spindle organizing protein 1 (MZT1) is a protein that plays a critical role in the organization and dynamics of mitotic spindles during cell division. MZT1 is a 21-kDa protein that is expressed in a variety of tissues, including muscle, brain, and testes. It is one of the key components of the mitotic spindle, which is a complex structure that pulls the chromosomes apart during cell division to ensure accurate replication.

MZT1 is a protein that is expressed in a variety of tissues and is involved in the organization and dynamics of the mitotic spindle.

MZT1 has been shown to play a critical role in the regulation of mitotic spindle organization and dynamics. It is one of the key components of the spindle and is involved in the formation and maintenance of the spindle structure. MZT1 has been shown to interact with several other proteins, including the protein T-complex, which is involved in the regulation of mitotic spindle organization and dynamics.

MZT1 has also been shown to play a critical role in the regulation of cell division. It is involved in the regulation of the G1/S transition, which is the stage of cell division where the cell prepares for cell division by producing more DNA and organizing the cytoskeleton. MZT1 has been shown to inhibit the G1/S transition and to promote the G0/G1 transition, which is the stage of cell division where the cell prepares for cell division by producing more DNA and organizing the cytoskeleton.

MZT1 has also been shown to play a critical role in the regulation of cellular signaling. It is involved in the regulation of several signaling pathways, including the TGF-β pathway, which is involved in the regulation of cell growth, differentiation, and survival. MZT1 has been shown to interact with the protein SMAD, which is involved in the regulation of TGF-β signaling.

MZT1 has been shown to play a critical role in the regulation of cellular transport. It is involved in the regulation of the trafficking of several proteins, including the protein synaptonemal complex (SNC), which is involved in the transport of the chromosomes during cell division. MZT1 has been shown to interact with the protein p18, which is involved in the regulation of SNC transport.

MZT1 has also been shown to play a critical role in the regulation of cellular adhesion. It is involved in the regulation of the formation and maintenance of tight junctions, which are specialized structures that mediate cell-cell communication. MZT1 has been shown to interact with the protein ZNF2, which is involved in the regulation of tight junction formation.

In conclusion, MZT1 is a protein that plays a critical role in the organization and dynamics of mitotic spindles during cell division. Its functions include regulating the G1/S transition, the regulation of cell division, the regulation of cellular signaling, and the regulation of cellular transport. MZT1 is a potential drug target and biomarker for cancer. Further research is needed to fully understand the functions of MZT1 and its potential as a drug.

Protein Name: Mitotic Spindle Organizing Protein 1

Functions: Required for gamma-tubulin complex recruitment to the centrosome

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