N6AMT1: A Role in DNA Methylation and Cellular Processes (G29104)

Target Name: N6AMT1

NCBI ID: G29104

N6AMT1: A Role in DNA Methylation and Cellular Processes

N6AMT1 (n(6)-adenine-specific DNA methyltransferase 1) is a gene that encodes a protein that plays a critical role in the regulation of DNA methylation. Specifically, it is involved in the demethylation of the promoter region of the gene N6-adenine-specific DNA methyltransferase gene (N6AMT2), which encodes a protein that is responsible for methylating the promoter region of the N6-adenine-specific DNA methyltransferase gene.

The N6AMT1 gene was first identified in 2016 using DNA-based approaches, and its function has since been extensively studied. It is located on chromosome 6 and has been shown to be involved in the regulation of various cellular processes, including cell growth, apoptosis, and gene expression.

One of the key functions of N6AMT1 is its ability to demethylate the promoter region of the N6-adenine-specific DNA methyltransferase gene. This process is critical for the regulation of gene expression, as the methylation of a gene's promoter region can inhibit its ability to be translated into protein. By demethylating the promoter region, N6AMT1 allows the N6-adenine-specific DNA methyltransferase gene to be expressed and its protein to be produced.

In addition to its role in demethylation, N6AMT1 has also been shown to play a role in the regulation of cell growth and apoptosis. It has been shown to be involved in the regulation of cell cycle progression, and to play a role in the programmed cell death (apoptosis) pathway.

N6AMT1 has also been shown to be involved in the regulation of stem cell maintenance and proliferation. It has been shown to be involved in the regulation of the stem cell maintenance and proliferation, and to play a role in the development and maintenance of cancer stem cells.

In conclusion, N6AMT1 is a gene that encodes a protein that is involved in the regulation of various cellular processes, including cell growth, apoptosis, and stem cell maintenance. Its function as a drug target or biomarker is of great interest, as it may provide new insights into the regulation of these processes and may be a useful target for the development of new therapeutic approaches. Further research is needed to fully understand the functions of N6AMT1 and its potential as a drug or biomarker.

Protein Name: N-6 Adenine-specific DNA Methyltransferase 1

Functions: Methyltransferase that can methylate proteins and, to a lower extent, arsenic (PubMed:18539146, PubMed:21193388, PubMed:30017583, PubMed:31636962, PubMed:31061526). Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators (PubMed:31061526). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:18539146, PubMed:31632689, PubMed:31636962). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:18539146, PubMed:20606008, PubMed:31636962, PubMed:31061526). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (PubMed:21193388, PubMed:25997655). It however only plays a limited role in arsenic metabolism compared with AS3MT (PubMed:25997655)

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