Target Name: MUC4
NCBI ID: G4585
Other Name(s): Mucin-4 beta chain | ascites sialoglycoprotein | Mucin 4 | Sv0 | MUC4 variant 6 | Ascites sialoglycoprotein 1 | mucin 4, cell surface associated | Mucin-4 | Ascites sialoglycoprotein | Mucin-4 (isoform d) | ASGP-1 | testis mucin | MUC4_HUMAN | Mucin 4, cell surface associated, transcript variant 4 | Testis mucin | Pancreatic adenocarcinoma mucin | Mucin 4, cell surface associated, transcript variant 6 | HSA276359 | tracheobronchial mucin | Mucin-4 (isoform a) | Mucin-4 (isoform 6) | ASGP | Mucin-4 alpha chain | pancreatic adenocarcinoma mucin | mucin 4, tracheobronchial | Tracheobronchial mucin | MUC4 variant 1 | MUC4 variant 4 | Mucin 4, cell surface associated, transcript variant 1 | MUC-4 | ASGP-2 | Mucin 4, tracheobronchial | Ascites sialoglycoprotein 2

MUC4: A Transmembrane Glycoprotein Involved in Various Physiological Processes and Diseases

MUC4 (Mucin-4 beta chain), also known as MUC4-AS1, is a transmembrane glycoprotein that is expressed in various tissues throughout the body, including the skin, gut, airway, and uterine lining. It is one of the four known transmembrane glycoproteins that encapsulate secretions from the simple endocrine cells (SMC),. MUC4 is a member of the Mucin family, which is characterized by the presence of a secretory portion of the protein that contains a hydrophobic transmembrane region and a hydrophilic cytoplasmic region.

MUC4 is well characterized in the mouse, human, and other organisms. It is a cell surface glycoprotein that is involved in various physiological processes, including cell signaling, tissue structure, and immune response. MUC4 is involved in several different signaling pathways , including the TGF-灏? pathway, which plays a role in cell growth, differentiation, and survival.

MUC4 has also been shown to be a potential drug target in several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Its potential as a drug target is due to its unique structure and the various functions that it plays in the body.

One of the main functions of MUC4 is its role in cell signaling. MUC4 is involved in several different signaling pathways, including the TGF-灏? pathway, which plays a role in cell growth, differentiation, and survival. MUC4 is a critical protein in this pathway, as it helps to regulate the activity of TGF-灏?1, which is a potent regulator of cell growth and differentiation.

In addition to its role in cell signaling, MUC4 is also involved in the formation of tissues and organs. MUC4 is a key component of the intercellular matrix (ICM), which is the complex of cells that creates the tissue structure and provides support for the mechanical properties of the body. MUC4 helps to regulate the structure and composition of the ICM, ensuring that tissues and organs maintain their proper shape and function.

MUC4 is also involved in several different diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Its potential as a drug target is due to its unique structure and the various functions that it plays in the body.

MUC4 has also been shown to be involved in the development and progression of several types of cancer, including breast, ovarian, and prostate cancer. MUC4 has also been shown to be involved in the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In addition, MUC4 has been implicated in several autoimmune diseases, including rheumatoid arthritis and Crohn's disease.

In conclusion, MUC4 is a transmembrane glycoprotein that is involved in various physiological processes and plays a critical role in the development and progression of several types of cancer, neurodegenerative diseases, and autoimmune diseases. Its unique structure and various functions make it an attractive drug target for the development of new treatments for these diseases.

Protein Name: Mucin 4, Cell Surface Associated

Functions: Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces (PubMed:10880978). These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation (PubMed:10880978). Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation

More Common Targets

MUC5AC | MUC5B | MUC6 | MUC7 | MUC8 | Mucin | MUCL1 | MUCL3 | MUL1 | Multisubunit histone acetyltransferase complex | MUPP | MUS81 | Muscarinic Acetylcholine Receptor (mAChR) | MUSK | MUSTN1 | MUTYH | MVB12A | MVB12B | MVD | MVK | MVP | MX1 | MX2 | MXD1 | MXD3 | MXD4 | MXI1 | MXRA5 | MXRA5Y | MXRA7 | MXRA8 | MYADM | MYADML | MYADML2 | MYB | MYBBP1A | MYBL1 | MYBL2 | MYBPC1 | MYBPC2 | MYBPC3 | MYBPH | MYBPHL | MYC | MYCBP | MYCBP2 | MYCBP2-AS1 | MYCBPAP | MYCL | MYCL-AS1 | MYCLP1 | MYCN | MYCNOS | MYCNUT | MYCT1 | MYD88 | MYDGF | MYEF2 | Myelin Protein | MYEOV | MYF5 | MYF6 | MYG1 | MYH1 | MYH10 | MYH11 | MYH13 | MYH14 | MYH15 | MYH16 | MYH2 | MYH3 | MYH4 | MYH6 | MYH7 | MYH7B | MYH8 | MYH9 | MYHAS | MYL1 | MYL10 | MYL11 | MYL12A | MYL12B | MYL12BP3 | MYL2 | MYL3 | MYL4 | MYL5 | MYL6 | MYL6B | MYL7 | MYL9 | MYLIP | MYLK | MYLK-AS1 | MYLK-AS2 | MYLK2 | MYLK3 | MYLK4