Target Name: MVB12B
NCBI ID: G89853
Other Name(s): MVB12B variant 1 | Multivesicular body subunit 12B (isoform 1) | C9orf28 | Multivesicular body subunit 12B, transcript variant 1 | Multivesicular body subunit 12B, transcript variant 2 | Protein FAM125B | MB12B_HUMAN | multivesicular body subunit 12B | MVB12B variant 2 | Multivesicular body subunit 12B | FAM125B | ESCRT-I complex subunit MVB12B | Multivesicular body subunit 12B (isoform 2) | family with sequence similarity 125, member B | Family with sequence similarity 125, member B

MVB12B: A Potential Drug Target for Neurodegenerative Diseases

MVB12B, also known as MVB12B variant 1, is a protein that is expressed in various tissues of the body, including the brain, heart, and liver. It is a member of the venom proteome family 12B, which is characterized by the presence of a characteristic domain called P120. P120 is a transmembrane protein that contains a catalytic active site and a N-terminal extracellular domain.

One of the unique features of MVB12B is its ability to induce apoptosis (programmed cell death) in various cell types. This property makes MVB12B a potential drug target or biomarker for a variety of diseases.

In addition to its ability to induce apoptosis, MVB12B is also known for its role in cell signaling pathways. It is a positive regulator of the protein kinase B (PKB) and has been shown to play a role in the regulation of various cellular processes, including cell adhesion, migration, and survival.

The MVB12B gene has been identified and its expression has been verified in various tissues and cell types. It is also known to be expressed in the brains of individuals with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. This suggests that MVB12B may be a useful biomarker or drug target for these diseases.

Furthermore, MVB12B has also been shown to be involved in the regulation of pain perception and neuroinflammation. It has been shown to reduce pain sensitivity in animal models and to protect against neuroinflammation in rat models of multiple sclerosis.

In addition to its potential role in disease, MVB12B also has potential as a drug target. Several studies have shown that MVB12B can be targeted by small molecules and antibodies, and that these treatments can induce apoptosis in MVB12B-expressing cells. Additionally, MVB12B has been shown to interact with various signaling pathways, including the PI3K/Akt signaling pathway. This suggests that MVB12B may be a useful target for inhibitors of this pathway, which could be useful for treating various diseases.

In conclusion, MVB12B is a protein that has been identified and characterized for its ability to induce apoptosis and its role in cell signaling pathways. Its potential as a drug target or biomarker for various diseases makes it an attractive target for further research and development. Further studies are needed to fully understand the role of MVB12B in disease and to develop effective treatments.

Protein Name: Multivesicular Body Subunit 12B

Functions: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies

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