MYO18A: A Protein Critical for Muscle Contraction and Relaxation

Target Name: MYO18A

NCBI ID: G399687

MYO18A: A Protein Critical for Muscle Contraction and Relaxation

Myosin is a protein that plays a crucial role in muscle contraction and relaxation. It is made up of several subunits that include the myosin heads, which contain the protein Myosin light chain, and the myosin bottleneck, which contains the protein Myosin heavy chain. The myosin heads contain the ATP-binding site, which is the site where the muscle can bind to and release ATP to generate force during muscle contraction. The myosin bottleneck contains the regulatory domain, which is responsible for regulating the myosin heads and controlling the rate of muscle contraction.

PDZ domains are a type of protein that are found in a variety of organisms, including humans. They are characterized by a characteristic domain that consists of a hydrophobic core and a transmembranespanning region. PDZ domains have been shown to play a variety of roles in various cellular processes, including intracellular signaling, cell-cell adhesion, and protein-protein interactions.

MYO18A, also known as Myosin heavy chain, is a protein that is made up of multiple PDZ domains. It is a key component of the myosin machinery, which is responsible for generating muscle contraction during muscle relaxation.MYO18A is a 18-kDa protein that is composed of multiple PDZ domains that are located throughout the myosin molecule.

MYO18A functions as a critical protein for muscle contraction and relaxation. It plays a key role in regulating the myosin heads, which are the protein Myosin light chain and the protein Myosin heavy chain.MYO18A is able to interact with the myosin heads and regulate the rate of muscle contraction.

MYO18A is also involved in the regulation of muscle relaxation. During muscle relaxation, the myosin heads are released from the myosin filaments, and the myosin bottleneck is able to interact with other regulatory proteins to regulate the rate of muscle relaxation.

MYO18A is a potential drug target for muscle-related diseases. Currently, there are no FDA-approved drugs that are specifically targeted at MYO18A. However, research is being conducted to investigate the potential benefits and risks of targeting MYO18A.

MYO18A is also a potential biomarker for muscle-related diseases. The levels of MYO18A have been shown to be elevated in a variety of muscle-related conditions, including muscle dystrophy, myopathies, and myotonic dystrophy.

Conclusion

MYO18A is a protein that is made up of multiple PDZ domains and plays a critical role in the myosin machinery. It is involved in the regulation of muscle contraction and relaxation, and is a potential drug target and biomarker for muscle-related diseases. Further research is needed to fully understand the role of MYO18A in muscle biology and to develop effective treatments for muscle-related conditions.

Protein Name: Myosin XVIIIA

Functions: Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation

More Common Targets