MYRF: A Potential Drug Target and Biomarker (G745)

Target Name: MYRF

NCBI ID: G745

MYRF: A Potential Drug Target and Biomarker

MYRF (Myeloid-derived suppressor factor), also known as KIAA0954, is a protein that is expressed in the myeloid cells of the human body. It is a member of the TGF-β pathway, which is a well-known signaling pathway that regulates cell growth, differentiation, and survival.MYRF has been identified as a potential drug target and biomarker for various diseases, including cancer, inflammation, and autoimmune disorders.

MYRF is expressed in a variety of tissues and cells in the human body, including the bone marrow, where it plays a role in the regulation of myeloid cell development and function. It is also expressed in other tissues, such as the liver, where it has been shown to play a role in the regulation of cell growth and differentiation.MYRF is a 21-kDa protein that consists of 105 amino acid residues. It has a molecular weight of 19,511 Da and a calculated pI of 4.99.

MYRF is involved in the regulation of multiple cellular processes in the body, including cell growth, differentiation, and survival. It is a key regulator of myeloid cell development and function, and has been shown to play a role in the regulation of bone marrow microenvironment, where it is involved in the regulation of stem cell proliferation and differentiation.MYRF is also involved in the regulation of immune cell function, and has been shown to play a role in the regulation of T cell development and function.

MYRF has been shown to be a potential drug target for a variety of diseases, including cancer, inflammation, and autoimmune disorders. In cancer, MYRF has been shown to play a role in the regulation of cancer cell growth and survival. For example, studies have shown that high levels of MYRF in cancer cells can enhance their ability to evade the effects of chemotherapy and radiation therapy.MYRF has also been shown to play a role in the regulation of inflammatory responses, and has been shown to play a role in the regulation of chronic pain.

MYRF has been shown to be a potential biomarker for a variety of diseases, including cancer, inflammation, and autoimmune disorders. For example, studies have shown that levels of MYRF in blood samples from patients with cancer are often elevated compared to levels in healthy individuals.MYRF has also been shown to be involved in the regulation of immune cell function, and has been shown to play a role in the regulation of T cell development and function.

MYRF is also involved in the regulation of cellular processes in the body, including cell growth, differentiation, and survival. It is a key regulator of myeloid cell development and function, and has been shown to play a role in the regulation of bone marrow microenvironment, where it is involved in the regulation of stem cell proliferation and differentiation.MYRF is also involved in the regulation of immune cell function, and has been shown to play a role in the regulation of T cell development and function.

In conclusion, MYRF is a protein that is expressed in the myeloid cells of the human body. It is a member of the TGF-β pathway and is involved in the regulation of multiple cellular processes in the body.MYRF has been identified as a potential drug target and biomarker for a variety of diseases, including cancer, inflammation, and autoimmune disorders. Further research is needed to fully understand the role of MYRF in the regulation of cellular processes in the body and its potential as a drug target.

Protein Name: Myelin Regulatory Factor

Functions: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832)

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