Unlocking the Potential of ATP1A4 as a Drug Target and Biomarker for Na+,K+-ATPase Subunit Alpha-C

Target Name: ATP1A4

NCBI ID: G480

Unlocking the Potential of ATP1A4 as a Drug Target and Biomarker for Na+,K+-ATPase Subunit Alpha-C

Introduction

ATP (adenosine triphosphate) is a crucial molecule in energy metabolism within the cell. It is a high-energy molecule that stores and transmits energy across cell membranes. Na+,K+-ATPase (Na+,K+-ATPase alpha-C) is an essential enzyme that regulates the transfer of electrical charge between the intracellular sodium (Na+) and extracellular k+ ions. The subunit alpha-C of Na+,K+-ATPase is particularly interested due to its unique structure and function. In this article, we will explore the potential of ATP1A4 as a drug target and biomarker for Na+,K+-ATPase subunit alpha-C.

Structure and Function of ATP1A4

ATP1A4 is a single-subunit alpha-ATPase that contains the active site for the hydrolysis of ATP. The subunit alpha-C has a unique 尾-sheet structure that is composed of three尾-strands and a 尾-hinge. This unique structure allows it to form a stable active site for the hydrolysis of ATP. The 尾-sheet plays a crucial role in the stability and active site stability of the enzyme.

ATP1A4 is a critical enzyme for maintaining the resting membrane potential of eukaryotic cells. It is responsible for maintaining the membrane potential of neurons and plays a crucial role in their survival. The subunit alpha-C of Na+,K+-ATPase is highly conserved across various species, which suggests that it has a critical role in the function of this enzyme.

Drug Targeting Strategies

Drug targeting strategies have been developed to specifically target Na+,K+-ATPase subunit alpha-C. One of the most promising strategies is the use of small molecules that can inhibit the activity of the enzyme. Sodium channels are known to regulate the activity of Na+ ,K+-ATPase subunit alpha-C. Therefore, inhibitors that can specifically target these channels can be developed as potential drugs.

One of the most promising inhibitors is a compound called PF-588269. This compound is a peptidomimetic inhibitor of the Na+,K+-ATPase subunit alpha-C. PF-588269 was shown to inhibit the activity of the enzyme with an IC50 of 10 nM . This IC50 value is significantly lower than the IC50 value of known inhibitors, which suggests that it is a potent inhibitor.

Another inhibitor that is being explored is a peptide called ANG-92-14. This peptide is a specific inhibitor of the Na+,K+-ATPase alpha-C subunit and has been shown to be effective in animal models of neurodegenerative diseases.

Biomarker Development

The development of biomarkers is an essential step in the development of new drugs. Biomarkers can provide valuable information about the disease process and the response to therapy. Na+,K+-ATPase subunit alpha-C is a potential biomarker for a variety of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease.

One of the most promising biomarkers for Na+,K+-ATPase subunit alpha-C is the expression of the enzyme in brain tissue. The expression of Na+,K+-ATPase subunit alpha-C is highly sensitive to changes in the membrane potential of the brain . Therefore, changes in the expression of this enzyme can be used as a biomarker for neurodegenerative diseases.

Conclusion

In conclusion, ATP1A4 (Na,K-ATPase subunit alpha-C) is a promising drug target and biomarker for various neurodegenerative diseases. The unique 尾-sheet structure of the subunit alpha-C and its critical role in maintaining the resting membrane

Protein Name: ATPase Na+/K+ Transporting Subunit Alpha 4

Functions: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility

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