TAS2R4: A Protein Involved in Taste and Cancer Treatment (G50832)

Target Name: TAS2R4

NCBI ID: G50832

TAS2R4: A Protein Involved in Taste and Cancer Treatment

TAS2R4 (Taste 2 receptor member 4) is a protein that is expressed in the taste buds of the tongue and is involved in the sense of taste. It is a member of the TAS2R family of transmembrane proteins, which are known for their role in taste and texture perception.

TAS2R4 is a 24-kDa protein that is expressed in the tongue epithelial cells, which are the cells that line the taste buds. It is localized to the basal turn of the tongue and is involved in the development and maintenance of the taste buds. TAS2R4 is a G protein-coupled receptor (GPCR), which means that it is involved in the transduction of signals from the taste buds to the brain.

TAS2R4 is involved in the sense of taste, specifically in the perception of sweet, sour, and bitter tastes. When TAS2R4 is activated by a taste substance, it causes a rapid increase in the electrical activity (known as an action potential) in the taste neurons. This increase in activity is then transduced to the brain, where it is interpreted as the sensation of taste.

TAS2R4 is a potent drug target for several diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. Its role in these diseases has led to the development of new treatments that can improve the quality of life for patients.

One of the ways that TAS2R4 is used to treat cancer is through the use of anti-TAS2R4 drugs. These drugs work by inhibiting the activity of TAS2R4, which can lead to the death of cancer cells. One of the most popular anti-TAS2R4 drugs is a class of drugs called tyrosine kinase inhibitors, which are used to treat a variety of cancers, including breast, lung, and colorectal cancers.

Another way that TAS2R4 is used to treat neurodegenerative diseases is through the use of drugs that target the TAS2R4 receptor. These drugs work by increasing the activity of TAS2R4, which can help to protect the brain from the effects of neurodegenerative diseases. One of the most popular TAS2R4 antagonists used to treat neurodegenerative diseases is a drug called RAS-Tas2R4, which is used to treat Alzheimer's disease and other forms of dementia.

In addition to its use in cancer and neurodegenerative diseases, TAS2R4 is also being targeted as a potential biomarker for several psychiatric disorders. Studies have shown that TAS2R4 levels are decreased in individuals with major depressive disorder (MDD) and schizophrenia, and that increasing TAS2R4 levels can improve the symptoms of these disorders. Therefore, TAS2R4 is being studied as a potential biomarker for MDD and schizophrenia.

TAS2R4 is also involved in the regulation of the taste reflex. When TAS2R4 is activated by a taste substance, it causes the muscles of the tongue to move food towards the front of the mouth, which is the location of the taste buds. This movement is what we

Protein Name: Taste 2 Receptor Member 4

Functions: Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency

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