TASP1: A Potential Drug Target for Amyloidosis (G55617)

Target Name: TASP1

NCBI ID: G55617

TASP1: A Potential Drug Target for Amyloidosis

TASP1 (SULEHS) is a protein that is expressed in the endoplasmic reticulum (ER) and is involved in the regulation of protein synthesis. It is a key regulator of the translation of mRNAs to proteins and is has been identified as a potential drug target in the disease amyloidosis.

Amyloidosis is a rare and progressive neurological disorder that is characterized by the accumulation of amyloid peptides in the brain. These peptides are generated by the misfolding of normal proteins, including the protein TASP1. The accumulation of amyloid peptides is thought to contribute to the neurotoxicity and progressive neurodegeneration associated with the disease.

TASP1 is a 21-kDa protein that is expressed in the ER and is involved in the regulation of protein synthesis through its role in the translocation of mRNAs to the ribosome. It is a key regulator of the translation of T-cell antigens, including the protein interleukin-2 (IL-2), which is important for the development and function of T cells.

TASP1 is also involved in the regulation of protein degradation, which is important for maintaining the levels of intracellular proteins and for preventing the accumulation of damaged or unnecessary proteins. This is important for maintaining the integrity of the endoplasmic reticulum, which is responsible for the quality control and folding of proteins.

The accumulation of amyloid peptides in the brain is thought to contribute to the neurotoxicity and progressive neurodegeneration associated with amyloidosis. TASP1 has been shown to be involved in the generation of amyloid peptides and has been identified as a potential drug target in the disease.

In conclusion, TASP1 (SULEHS) is a protein that is involved in the regulation of protein synthesis and the accumulation of amyloid peptides in the brain. It is a potential drug target in the disease amyloidosis and has the potential to be a useful therapeutic approach for the treatment of this progressive and neurodegenerative disorder. Further research is needed to fully understand the role of TASP1 in amyloidosis and to develop effective treatments.

Protein Name: Taspase 1

Functions: Protease responsible for KMT2A/MLL1 processing and activation (PubMed:14636557). It also activates KMT2D/MLL2 (By similarity). Through substrate activation, it controls the expression of HOXA genes, and the expression of key cell cycle regulators including CCNA1, CCNB1, CCNE1 and CDKN2A (By similarity) (PubMed:14636557)

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