TBX2: Overview of the Transcription Factor TBX2 (G6909)

Target Name: TBX2

NCBI ID: G6909

TBX2: Overview of the Transcription Factor TBX2

Summary

The T-box transcription factor TBX2 is a transcription factor widely expressed in multiple cell types. TBX2 has been shown to play an important role in a variety of diseases. Although TBX2 plays an important role in the body, there are currently no drugs targeting TBX2. This article aims to review the role of TBX2 in transcriptional regulation, disease occurrence and drug research, and to provide new ideas for the development and utilization of TBX2.

Keywords: T-box transcription factor; TBX2; transcriptional regulation; disease occurrence; drug research

1 Introduction

Transcription factors are an important class of proteins that play important roles in organisms. These factors control gene expression by binding to DNA. T-box transcription factors are a special class of transcription factors whose name comes from their conserved transcription binding domain (TBP). These factors are widely expressed in multiple cell types and play important roles in a variety of biological processes. TBX2 is a T-box transcription factor expressed in multiple cell types. This article will review the role of TBX2 in transcriptional regulation, disease occurrence and drug research, and provide new ideas for the development and utilization of TBX2.

2. Transcriptional regulation of TBX2

TBX2 plays an important role in transcriptional regulation. Research shows that TBX2 controls gene expression by binding to DNA. The binding site of TBX2 is located in the promoter region of the gene and binds to RNA polymerase. This binding results in an increase in the DNA-binding activity of TBX2, thereby enhancing gene expression.

The specific mechanism by which TBX2 plays a role in transcriptional regulation is not fully understood. However, studies have shown that the binding site of TBX2 is located in the promoter region of the gene and binds to RNA polymerase. This binding results in an increase in the DNA-binding activity of TBX2, thereby enhancing gene expression. In addition, TBX2 also binds to RNA-binding proteins, thereby further increasing RNA-binding activity.

3. Association between TBX2 and diseases

TBX2 plays an important role in various diseases. Studies have shown that TBX2 is related to the occurrence of various cancers, including lung cancer, liver cancer, breast cancer, etc. In addition, TBX2 is associated with a variety of autoimmune, metabolic and neurodegenerative diseases.

The specific mechanism between TBX2 and disease occurrence is not yet fully understood. However, research suggests that TBX2 plays a role in a variety of diseases, possibly by regulating gene expression. In addition, TBX2 may also be involved in immune cell activity

Protein Name: T-box Transcription Factor 2

Functions: Transcription factor which acts as a transcriptional repressor (PubMed:11111039, PubMed:11062467, PubMed:12000749, PubMed:22844464, PubMed:30599067). May also function as a transcriptional activator (By similarity). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:11111039, PubMed:12000749, PubMed:22844464, PubMed:30599067). Required for cardiac atrioventricular canal formation (PubMed:29726930). May cooperate with NKX2.5 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). May play a role as a positive regulator of TGFB2 expression, perhaps acting in concert with GATA4 in the developing outflow tract myocardium (By similarity). Plays a role in limb pattern formation (PubMed:29726930). Acts as a transcriptional repressor of ADAM10 gene expression, perhaps in concert with histone deacetylase HDAC1 as cofactor (PubMed:30599067). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX3 (By similarity). Required, together with TBX3, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with TBX3, in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537). Acts as a negative regulator of expression of CDKN1A/p21, IL33 and CCN4; repression of CDKN1A is enhanced in response to UV-induced stress, perhaps as a result of phosphorylation by p38 MAPK (By similarity). Negatively modulates expression of CDKN2A/p14ARF and CDH1/E-cadherin (PubMed:11062467, PubMed:12000749, PubMed:22844464). Plays a role in induction of the epithelial-mesenchymal transition (EMT) (PubMed:22844464). Plays a role in melanocyte proliferation, perhaps via regulation of cyclin CCND1 (By similarity). Involved in melanogenesis, acting via negative modulation of expression of DHICA oxidase/TYRP1 and P protein/OCA2 (By similarity). Involved in regulating retinal pigment epithelium (RPE) cell proliferation, perhaps via negatively modulating transcription of the transcription factor CEBPD (PubMed:28910203)

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