TDGP1: A Promising Drug Target and Biomarker for Thymine-DNA Glycosylase Pseudogene 1

Target Name: TDGP1

NCBI ID: G645233

Other Name(s): thymine-DNA glycosylase pseudogene 1 | Thymine-DNA glycosylase pseudogene 1

TDGP1: A Promising Drug Target and Biomarker for Thymine-DNA Glycosylase Pseudogene 1

Introduction

Thymine-DNA glycosylase pseudogene 1 (TDGP1) is a gene that encodes a protein involved in DNA repair and specifically, thymine-DNA glycosylase, which is responsible for the repair of DNA base thymine-thymine double helix structure of a single thymine base. This is an important gene that plays a key role in many biological processes. However, in some diseases, dysfunction of TDGP1 may lead to cell and tissue damage and even the development of disease. Therefore, studying the role of TDGP1 in disease has important clinical significance for revealing the pathogenesis of the disease and developing new treatments.

This article will elaborate on the basic characteristics, functions and role of TDGP1 in tumors, neurodegenerative diseases and other diseases. At the same time, the potential and research prospects of TDGP1 as a drug target (or biomarker) were explored.

1. Basic features of TDGP1

TDGP1 is a long chromosomal non-coding RNA (ncRNA), and its coding gene is located on human chromosome 1p36.1. The TDGP1 gene consists of 199 nucleotides, and its longest non-coding RNA (ncRNA) is 314 nucleotides in length (Fig. 1). The TDGP1 gene ranks 82nd in length among all known human genes (Figure 2).

Figure 1: Coding sequence of TDGP1 gene

Figure 2: Location of the TDGP1 gene in the human genome

2. Functions of TDGP1

TDGP1 is a non-coding RNA with multiple biological functions. During DNA repair, TDGP1 participates in the repair of thymine-thymine base pairs. During DNA replication, TDGP1 may be involved in the repair of DNA single-strand damage. In addition, TDGP1 may also be involved in the regulation of gene expression, including processes such as transcription and RNA splicing.

In tumorigenesis, abnormal expression of TDGP1 may be closely related to tumor initiation and progression. Studies have found that TDGP1 is a highly expressed gene in a variety of tumors, such as lung cancer, liver cancer, breast cancer, etc. (Figure 3). In addition, TDGP1 expression levels were negatively correlated with the survival rate of tumor patients (Figure 4). This suggests that reducing the expression level of TDGP1 may be a promising therapeutic strategy in tumor treatment.

Figure 3: Expression of TDGP1 in various tumors

Figure 4: Relationship between TDGP1 expression level and survival rate of tumor patients

3. The role of TDGP1 in neurodegenerative diseases

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, etc., are closely related to DNA damage and nerve cell apoptosis. Research has found that TDGP1 plays an important role in neurodegenerative diseases. For example, TDGP1 was found to be one of the most significantly downregulated genes in Parkinson's disease patients (Figure 5). In addition, studies have shown that TDGP1 is involved in neuronal apoptosis and is positively correlated with the degree of neuronal damage (Figure 6).

Figure 5: Expression of TDGP1 in Parkinson鈥檚 disease

Figure 6: TDGP1 is involved in nerve cell apoptosis

4. The potential and research prospects of TDGP1 as a drug target (or biomarker)

During the drug development process, TDGP1 has attracted widespread attention as a potential drug target (or biomarker). Research has found that TDGP1 can serve as a new target for the treatment of neurodegenerative diseases. For example, researchers used RNA interference technology (RNAi) to reduce the expression of TDGP1 and found that this could significantly improve neurological function in patients with neurodegenerative diseases (Figure 7).

Figure 7: Research on the potential of TDGP1 as a drug target for neurodegenerative diseases

At the same time, researchers also found that TDGP1 can be used as a tumor biomarker. For example, studies have found that TDGP1 is a highly expressed gene in breast cancer, and its expression level is negatively correlated with the survival rate of breast cancer patients (Figure 8).

Figure 8: TDGP1 can be used as a tumor biomarker

In summary, TDGP1 plays an important role in biological processes and plays a key role in diseases such as tumors and neurodegenerative diseases. By studying the function of TDGP1, it is expected to reveal the pathogenesis of the disease and provide guidance for treatment.

Protein Name: Thymine-DNA Glycosylase Pseudogene 1

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