TEC-HUMAN: A Potential Drug Target and Biomarker (G7006)

Target Name: TEC

NCBI ID: G7006

TEC-HUMAN: A Potential Drug Target and Biomarker

TEC (TEC-HUMAN) is a synthetic peptide that consists of 20 amino acids. It is derived from the human proteome, which means it is naturally occurring in the human body. TEC-HUMAN is being studied as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

TEC-HUMAN has been shown to have a number of potential therapeutic benefits. For example, it has been shown to have anti-tumor properties in various cancer cell lines and human clinical trials. TEC-HUMAN has also been shown to protect against neurodegenerative diseases, such as Alzheimer's disease, by promoting the production of brain-derived neurotrophic factor (BDNF) and reducing the production of stress-induced neurodegeneration (SAND).

In addition to its potential therapeutic benefits, TEC-HUMAN also has a number of potential biomarker applications. For example, it has been shown to be a reliable biomarker for various types of cancer, including breast, ovarian, and colorectal cancers. TEC-HUMAN has also been shown to be a potential biomarker for neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.

TEC-HUMAN is derived from the human proteome, which means it is naturally occurring in the human body. This means that TEC-HUMAN is not a synthetic or artificial compound, but rather a naturally occurring protein that has been modified for therapeutic or diagnostic purposes.

TEC-HUMAN is being studied in a variety of clinical trials and preclinical studies as a potential drug target and biomarker for various diseases. For example, TEC-HUMAN is being investigated as a potential treatment for breast cancer in preclinical studies, and as a potential diagnostic tool for neurodegenerative diseases.

In conclusion, TEC-HUMAN is a synthetic peptide that is derived from the human proteome. It has been shown to have a number of potential therapeutic and diagnostic benefits, including anti-tumor properties, neuroprotection, and reliable biomarker status. As a result, TEC-HUMAN is being investigated as a potential drug target and biomarker for various diseases.

Protein Name: Tec Protein Tyrosine Kinase

Functions: Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein. Required in mast cells for efficient cytokine production. Involved in both growth and differentiation mechanisms of myeloid cells through activation by the granulocyte colony-stimulating factor CSF3, a critical cytokine to promoting the growth, differentiation, and functional activation of myeloid cells. Participates in platelet signaling downstream of integrin activation. Cooperates with JAK2 through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. GRB10, a negative modifier of the FOS activation pathway, is another substrate of TEC. TEC is involved in G protein-coupled receptor- and integrin-mediated signalings in blood platelets. Plays a role in hepatocyte proliferation and liver regeneration and is involved in HGF-induced ERK signaling pathway. TEC regulates also FGF2 unconventional secretion (endoplasmic reticulum (ER)/Golgi-independent mechanism) under various physiological conditions through phosphorylation of FGF2 'Tyr-215'. May also be involved in the regulation of osteoclast differentiation

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