Target Name: TEFM
NCBI ID: G79736
Other Name(s): C17orf42 | Transcription elongation factor, mitochondrial | TEFM_HUMAN | transcription elongation factor, mitochondrial | transcription elongation factor of mitochondria

Targeting TEFM for Cancer and Metabolism

TEFM (C17orf42), also known as ALDH11A2, is a gene that has been identified as a potential drug target or biomarker for several diseases. The gene is located on chromosome 17 and has been shown to be involved in the regulation of various cellular processes, including cell signaling, DNA replication, and metabolism.

One of the key features of TEFM is its role in the development and progression of certain types of cancer. Studies have shown that TEFM mutations are frequently observed in various types of cancer, including breast, ovarian, and colorectal cancer. Additionally, altered expression of TEFM has also been observed in various types of cancer, including neuroendocrine and brain tumors.

Another potential drug target for TEFM is its role in the regulation of cell signaling. TEFM has been shown to play a role in the regulation of several signaling pathways, including the TGF-β pathway and the PI3K/Akt signaling pathway. These pathways are involved in various cellular processes, including cell growth, differentiation, and survival.

In addition to its role in cell signaling, TEFM is also involved in the regulation of DNA replication. Studies have shown that TEFM is involved in the regulation of DNA replication, including the loading of the DNA double helix into the nucleus and the regulation of the enzyme responsible for copying DNA.

Another potential drug target for TEFM is its role in the regulation of metabolism. TEFM has been shown to play a role in the regulation of various metabolic pathways, including cellular energy metabolism and metabolism of nutrients.

In conclusion, TEFM is a gene that has been identified as a potential drug target or biomarker for several diseases. Its role in the regulation of cell signaling, DNA replication, and metabolism makes it an attractive target for researchers to investigate further. Further studies are needed to determine the exact mechanisms by which TEFM functions as a drug target and to develop effective therapies for the treatment of diseases associated with TEFM mutations.

Protein Name: Transcription Elongation Factor, Mitochondrial

Functions: Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery

More Common Targets

TEK | TEKT1 | TEKT2 | TEKT3 | TEKT4 | TEKT4P1 | TEKT4P2 | TEKT5 | TEKTIP1 | TELO2 | Telomerase holoenzyme complex | TEN1 | TEN1-CDK3 | Teneurin | TENM1 | TENM2 | TENM2-AS1 | TENM3 | TENM3-AS1 | TENM4 | TENT2 | TENT4A | TENT4B | TENT5A | TENT5B | TENT5C | TENT5C-DT | TENT5D | TEP1 | TEPP | TEPSIN | TERB1 | TERB2 | TERC | TERF1 | TERF1P3 | TERF2 | TERF2IP | TERLR1 | TERT | TES | TESC | TESK1 | TESK2 | TESMIN | TESPA1 | TET1 | TET2 | TET2-AS1 | TET3 | Tetraspanin | TEX10 | TEX101 | TEX11 | TEX12 | TEX13A | TEX13B | TEX13C | TEX14 | TEX15 | TEX19 | TEX2 | TEX21P | TEX22 | TEX26 | TEX261 | TEX264 | TEX28 | TEX29 | TEX30 | TEX33 | TEX35 | TEX36 | TEX36-AS1 | TEX37 | TEX38 | TEX41 | TEX43 | TEX44 | TEX45 | TEX46 | TEX47 | TEX48 | TEX49 | TEX50 | TEX52 | TEX53 | TEX55 | TEX56P | TEX9 | TF | TFAM | TFAMP1 | TFAP2A | TFAP2A-AS1 | TFAP2A-AS2 | TFAP2B | TFAP2C | TFAP2D | TFAP2E