IMPG2: A Potential Drug Target for Cancer and Other Diseases (G50939)

Target Name: IMPG2

NCBI ID: G50939

IMPG2: A Potential Drug Target for Cancer and Other Diseases

IMPG2 (Immunomodulatory Proteomics Group 2) is a protein that is expressed in various tissues of the human body. It is a member of the IMP family, which includes proteins that play a crucial role in the immune response. The IMP family has been identified as a potential drug target in the treatment of various diseases, including cancer, autoimmune disorders, and neurodegenerative diseases.

IMPG2: Structure and Function

IMPG2 is a 21-kDa protein that is expressed in various tissues of the human body, including the spleen, thymus, spleen lymphocytes, peripheral blood T cells, and the placenta. It is characterized by a unique structure that consists of a long amino acid sequence that is predominantly alpha-helices and a short carboxylic acid tail.

The N-terminus of IMPG2 contains a characteristic Rossmann-fold, which is a conserved structural motif that is involved in protein-protein interactions. The Rossmann-fold is a structural motif that is composed of a specific arrangement of amino acids that are involved in the formation of a尾-sheet. This motif is thought to play a role in the stability and function of the protein.

The C-terminus of IMPG2 contains a single amino acid residue, which is a glutamic acid. This residue is known as Glu-192 and is involved in the protein's stability.

Functional Analysis of IMPG2

IMPG2 is involved in the immune response by regulating the production of T cells. T cells are a crucial immune cell that play a role in protecting the body against infection and disease. They are produced in the bone marrow and T-cell loci, and their development and function are regulated by various signaling pathways.

IMPG2 is involved in the regulation of T cell development by the T-cell receptor (TCR) signaling pathway. The TCR is a transmembrane protein that is involved in the recognition of antigens by T cells. The TCR is composed of a variable region and a constant region, and it is expressed in the T cells.

IMPG2 is known to be a negative regulator of TCR signaling. This means that it works to prevent the activity of the TCR and to regulate the production of T cells. It does this by interacting with the TCR and by modulating the activity of downstream signaling pathways.

IMPG2 has been shown to play a role in the regulation of T cell costimulation. Costimulation refers to the process by which T cells become co-stimulated by different antigens. This process is important for the regulation of T cell responses and is critical for the development of immune tolerance.

IMPG2 has also been shown to play a role in the regulation of T cell survival. T cells are a vital part of the immune system and are involved in protecting the body against infection and disease. They are regulated by various signaling pathways, including the T-cell receptor (TCR) signaling pathway.

IMPG2 has been shown to play a role in the regulation of T cell receptor (TCR) signaling pathway. The TCR is a transmembrane protein that is involved in the recognition of antigens by T cells. The TCR is composed of a variable region and a constant region, and it is expressed in the T cells.

IMPG2 is known to be a negative regulator of TCR signaling. This means that it works to prevent the activity of the TCR and to regulate the production

Protein Name: Interphotoreceptor Matrix Proteoglycan 2

Functions: Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin

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