INPP5K: Key Enzyme in PI3K/Akt Signaling Pathway (G51763)

Target Name: INPP5K

NCBI ID: G51763

INPP5K: Key Enzyme in PI3K/Akt Signaling Pathway

INPP5K, also known as phosphatidylinositol-4,5-bisphosphate 5-phosphatase, is a protein that is expressed in various tissues throughout the body. It is a key enzyme in the intracellular signaling pathway known as the PI3K/Akt signaling pathway, which is involved in a wide range of cellular processes, including cell signaling, cell survival, and cell growth.

The PI3K/Akt signaling pathway is a critical pathway that regulates many cellular processes, including cell signaling, cell survival, and cell growth. It is involved in the regulation of many different proteins, including many enzymes that are involved in the production of signaling molecules , such as neurotransmitters and hormones.

INPP5K is a key enzyme in the PI3K/Akt signaling pathway. It is the enzyme that catalyzes the breakdown of phosphatidylinositol-4,5-bisphosphate (PIP), which is a key signaling molecule in the pathway. PIP is produced by the breakdown of different types of lipids, including triacylglycerols (triglycerides) that are found in all types of cells.

The breakdown of PIP by INPP5K is a critical step in the PI3K/Akt signaling pathway. Once PIP is broken down, the resulting phosphate groups can be used to activate the Akt protein, which is a key regulator of the PI3K/Akt pathway. Activated Akt can then interact with other molecules, including the transcription factor p21, to promote the production of signaling molecules that regulate cellular processes such as cell growth, differentiation, and survival.

INPP5K is also involved in the regulation of many different cellular processes, including cell signaling, cell survival, and cell growth. It is involved in the production of many different signaling molecules, including several that are involved in the regulation of cell death. For example , INPP5K is involved in the production of rank protein (p18), which is a protein that is involved in the regulation of cell death.

INPP5K is also involved in the regulation of many different cellular processes, including cell signaling, cell survival, and cell growth. It is involved in the production of many different signaling molecules, including several that are involved in the regulation of cell growth. For example , INPP5K is involved in the production of S6 protein, which is a key regulator of the cell signaling pathway.

In conclusion, INPP5K is a key enzyme in the PI3K/Akt signaling pathway. It is involved in the breakdown of PIP and the regulation of many different cellular processes, including cell signaling, cell survival, and cell growth. As a result, INPP5K may be a potential drug target or biomarker for a wide range of diseases. Further research is needed to fully understand the role of INPP5K in cellular signaling and to develop effective treatments for the many diseases that are associated with this pathway.

Protein Name: Inositol Polyphosphate-5-phosphatase K

Functions: Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (PubMed:10753883, PubMed:16824732). Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate (PubMed:10753883). Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity)

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