INTS4: A Protein Involved in Cell-cell and Cell-matrix Interactions and Potential Drug Targets

Target Name: INTS4

NCBI ID: G92105

INTS4: A Protein Involved in Cell-cell and Cell-matrix Interactions and Potential Drug Targets

INTS4 (INT4) is a protein that is expressed in various tissues of the body, including the brain, heart, and gastrointestinal tract. It is a member of the Integrin family of proteins, which are involved in cell-cell and cell-matrix interactions. INTS4 has been shown to play a role in several physiological processes, including cell adhesion, migration, and invasion.

One of the unique features of INTS4 is its ability to interact with heparan sulfate, a type of carbohydrate found in the extracellular matrix (ECM). Heparan sulfate is known for its ability to regulate the activity of integrins, which are proteins that help cells stick together and form tissues. By interacting with INTS4, heparan sulfate has been shown to play a role in the regulation of cell-cell and cell-matrix interactions, as well as in the development and progression of several diseases, including cancer.

INTS4 has also been shown to be involved in the regulation of cell proliferation and differentiation. It has been shown to promote the growth and survival of cancer cells, as well as to inhibit the growth and survival of healthy cells. This suggests that INTS4 may be a potential drug target or biomarker for cancer.

Another potential role for INTS4 is its role in the regulation of inflammation. It has been shown to play a role in the regulation of immune cell function, as well as in the regulation of inflammation. This suggests that INTS4 may be a potential drug target or biomarker for inflammatory diseases.

INTS4 has also been shown to play a role in the regulation of pain perception. It has been shown to interact with a protein called TrkB, which is involved in the regulation of pain sensitivity. This suggests that INTS4 may be a potential drug target or biomarker for pain management diseases.

Overall, INTS4 is a protein that has been shown to play a role in several physiological processes, including cell adhesion, migration, and invasion, as well as in the regulation of cell proliferation and differentiation, inflammation, and pain perception. These properties make it a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of INTS4 in these processes and its potential as a drug.

Protein Name: Integrator Complex Subunit 4

Functions: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267)

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