INSM1: A Key Regulator and Potential Drug Target (G3642)

Target Name: INSM1

NCBI ID: G3642

INSM1: A Key Regulator and Potential Drug Target

INSM1, a zinc finger protein, is a key regulator of various cellular processes that are vital for human health and development. INSM1 has been identified as a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.

Overview of INSM1

INSM1 is a member of the INSM family, which includes several similar proteins that play a crucial role in regulating gene expression and cellular processes. INSM1 is a 21-kDa protein that is expressed in various tissues and cells of the body. It is highly conserved and has a conserved catalytic core, which is responsible for its unique function in cellular processes.

INSM1 functions as a regulator of gene expression by binding to specific DNA sequences and modulating the activity of transcription factors. This interaction between INSM1 and transcription factors allows INSM1 to regulate the expression of target genes, thereby controlling cellular processes such as cell growth, apoptosis, and inflammation.

Drug Targeting and Biomarker

INSM1 has been identified as a potential drug target due to its unique mechanism of action and its involvement in various diseases. The development of INSM1-targeted drugs could provide new treatment options for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.

One of the INSM1-targeted drugs is currently in clinical trials for the treatment of neurodegenerative disorders, such as Alzheimer's disease. This drug works by inhibiting the activity of INSM1 and increasing the levels of a protein called TrkB, which is known to promote the growth and survival of brain cells.

Another INSM1-targeted drug is being developed for the treatment of cancer. This drug works by inhibiting the activity of INSM1 and inhibiting the formation of blood vessels, which is a critical source of oxygen and nutrients for cancer cells.

Biomarker

INSM1 has also been identified as a potential biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. The levels of INSM1 have been found to be elevated in various tissues and diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.

In addition, INSM1 has been shown to be involved in the regulation of cellular processes that are critical for human health and development. For example, INSM1 has been shown to regulate the growth and differentiation of stem cells, which are vital for the development and repair of tissues in the body.

Conclusion

INSM1 is a unique protein that plays a crucial role in regulating cellular processes and has been identified as a potential drug target and biomarker for various diseases. The development of INSM1-targeted drugs could provide new treatment options for diseases that are currently untreated or have limited treatment options. Further research is needed to fully understand the role of INSM1 in cellular processes and its potential as a drug target and biomarker.

Protein Name: INSM Transcriptional Repressor 1

Functions: Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (PubMed:23721412). Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation

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