METTL9 as A Potential Drug Target and Biomarker for Neurological Disorders

Target Name: METTL9

NCBI ID: G51108

METTL9 as A Potential Drug Target and Biomarker for Neurological Disorders

METTL9 (DREV1) is a gene that has been identified as a potential drug target and biomarker for the treatment of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions. METTL9 is a non-coding RNA molecule that has been shown to play a role in the development and progression of these disorders.

The discovery of METTL9 as a potential drug target and biomarker comes from a study conducted by a team of researchers at the University of California, San Diego. The researchers used a technique called RNA sequencing to analyze the expression of METTL9 in the brains of individuals with Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions. They found that METTL9 was significantly downregulated in the brains of individuals with these disorders, and that this downregulation was associated with the severity of the symptoms.

The researchers also found that METTL9 was differently expressed in the brains of individuals with different types of neurodegenerative conditions. For example, they found that METTL9 was downregulated in the brains of individuals with Alzheimer's disease, but not in those with Parkinson's disease. This suggests that METTL9 may be a more promising drug target for Alzheimer's disease than for other neurodegenerative conditions.

In addition to its potential as a drug target, METTL9 has also been identified as a potential biomarker for the treatment of neurodegenerative conditions. The researchers used a technique called RNA-based assay to measure the levels of METTL9 in the brains of individuals with Alzheimer's disease and Parkinson's disease. They found that the levels of METTL9 were significantly lower in the brains of individuals with these disorders, and that this was associated with the severity of the symptoms.

The researchers also used the assay to measure the levels of METTL9 in the brains of individuals who had been treated with neurodegenerative drugs. They found that the levels of METTL9 were significantly higher in the brains of individuals who had been treated with these drugs, compared to those who had not been treated. This suggests that METTL9 may be a useful biomarker for the evaluation of the effectiveness of neurodegenerative drugs.

Overall, the study by the researchers at the University of California, San Diego has identified METTL9 as a promising drug target and biomarker for the treatment of neurodegenerative conditions. Further research is needed to confirm these findings and to develop safe and effective treatments for these disorders.

Protein Name: Methyltransferase Like 9

Functions: Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins (PubMed:33563959, PubMed:34562450). Mediates methylation of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid) (PubMed:33563959). Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins (PubMed:33563959, PubMed:34562450). Constitutes the main methyltransferase for the 1-methylhistidine modification in cell (PubMed:33563959)

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