Exploring the Potential Drug Target CEP83: A Review of its Characteristics and Therapeutic Potential

Target Name: CEP83

NCBI ID: G51134

Exploring the Potential Drug Target CEP83: A Review of its Characteristics and Therapeutic Potential

Abstract:

CEP83, also known as CEP83-HUMAN, is a protein that is expressed in various tissues of the human body. Its function and regulation have been extensively studied, providing insights into the potential drug targets it may serve. This review summarizes the current understanding of CEP83, including its expression, function, and potential therapeutic applications.

Introduction:

CEP83 is a transmembrane protein that is expressed in various tissues of the human body, including the brain, heart, lungs, and kidneys. Its function is not well understood, but it is involved in various physiological processes, including cell signaling, neurotransmitter release, and inflammation.

Potential Drug Targets:

CEP83 has been identified as a potential drug target due to its unique structure and expression pattern. Its high degree of expression in multiple tissues makes it an attractive target for small molecules that can modulate its activity.

One of the most promising aspects of CEP83 is its role in neurotransmission. CEP83 has been shown to play a role in the regulation of neurotransmitter release, including the release of dopamine and serotonin. Additionally, CEP83 has been shown to interact with various neurotransmitter receptors, including dopamine, serotonin, and GABA.

Another potential drug target for CEP83 is its role in inflammation. CEP83 has been shown to be involved in the regulation of inflammation and immune cell function. Its involvement in inflammation may make it an attractive target for anti-inflammatory drugs.

Chemical Compounds:

Several chemical compounds have been identified as potential drug candidates for CEP83. One of the most promising compounds is a small molecule called W-8, which is a potent inhibitor of CEP83-mediated neurotransmission. W-8 was shown to block the release of dopamine and serotonin in cultures of brain cells, suggesting that it may have potential as a treatment for neurotransmission disorders.

Another compound that has been shown to interact with CEP83 is a peptide called P2-83, which contains a unique sequence that is specifically derived from CEP83. P2-83 has been shown to interact with CEP83 and to modulate its activity in a similar way to W-8, suggesting that it may also be a promising drug candidate.

Conclusion:

CEP83 is a protein that has been extensively studied for its function and regulation. Its unique structure and expression pattern make it an attractive target for small molecules that can modulate its activity. The potential drug targets for CEP83, including neurotransmission and inflammation, provide a promising direction for future research. Further studies are needed to fully understand the function and potential of CEP83 as a drug target.

Protein Name: Centrosomal Protein 83

Functions: Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly

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