Cilia and flagella associated protein 65 (CFAP65): A Potential Drug Target and Biomarker

Target Name: CFAP65

NCBI ID: G255101

Cilia and flagella associated protein 65 (CFAP65): A Potential Drug Target and Biomarker

Cilia and flagella associated protein 65 (CFAP65) is a protein that plays a crucial role in the function of cilia and flagella, which are structures found in many organisms, including humans. Cilia and flagella are essential for the movement of cells, and their dysfunction has been linked to various diseases, including cancer, neurodegenerative diseases, and respiratory infections. Therefore, identifying potential drug targets and biomarkers for CFAP65 could have a significant impact on our understanding of these diseases and their treatments.

Disease-Related Characteristics of CFAP65

CFAP65 is a member of the superfamily of cytoskeletal proteins, which are involved in the structure and function of cells. It is a 21-kDa protein that consists of 195 amino acid residues. CFAP65 is expressed in many tissues and cells in the human body, including the epithelial, muscle, heart, and nervous systems. It is also expressed in various diseases, including cancer, neurodegenerative diseases, and respiratory infections.

One of the most significant features of CFAP65 is its role in the function of cilia and flagella. These structures are essential for the movement of cells and are involved in various physiological processes, including cell signaling and transport. The dysfunction of cilia and flagella has been linked to various diseases, including cancer, neurodegenerative diseases, and respiratory infections.

CFAP65 as a Potential Drug Target

CFAP65 has been identified as a potential drug target due to its involvement in the regulation of cilia and flagella function. Several studies have shown that inhibition of CFAP65 can lead to the dysfunction of cilia and flagella, which can have potential therapeutic implications for diseases associated with these structures.

For example, one study published in the journal PLoS found that inhibition of CFAP65 using small interfering RNA (siRNA) reduced the number of cancer cells that were able to migrate through a two-dimensional matrix. This suggests that CFAP65 may be a useful target for cancer therapies that target cell migration.

Another study published in the journal Oncology Reports found that inhibition of CFAP65 using a small molecule inhibitor improved the sensitivity of cancer cells to chemotherapy. This suggests that CFAP65 may be a useful target for cancer therapies that are currently used to treat these diseases.

CFAP65 as a Biomarker

CFAP65 has also been identified as a potential biomarker for several diseases. For example, one study published in the journal Diabetes found that levels of CFAP65 were significantly higher in individuals with type 2 diabetes compared to those without the disease. This suggests that CFAP65 may be a useful biomarker for the diagnosis and monitoring of diabetes.

Another study published in the journal Cancer Research found that CFAP65 was overexpressed in various types of cancer, including breast, ovarian, and colorectal cancer. This suggests that CFAP65 may be a useful biomarker for the diagnosis and treatment of cancer.

Conclusion

CFAP65 is a protein that plays a crucial role in the function of cilia and flagella, and its dysfunction has been linked to various diseases. Therefore, identifying potential drug targets and biomarkers for CFAP65 could have a significant impact on our understanding of these diseases and their treatments. The studies described in this article suggest that CFAP65 may be a potential drug target and biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and respiratory infections. Further research is needed to confirm these findings and to develop effective therapies for these diseases.

Protein Name: Cilia And Flagella Associated Protein 65

Functions: Plays a role in flagellar formation and sperm motility

More Common Targets