CHD4: A Potential Drug Target and Biomarker for Cancer Treatment

Target Name: CHD4

NCBI ID: G1108

CHD4: A Potential Drug Target and Biomarker for Cancer Treatment

Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a protein that plays a crucial role in the regulation of DNA replication and repair in various organisms, including humans. CHD4 is a member of the chromatin-remodeling complex (CRC), which is responsible for the maintenance of DNA integrity and the regulation of gene expression. CHD4 functions as a helicase, which means it can physically manipulate the DNA double helix, and it also has a DNA-binding domain that can interact with specific DNA sequences.

The search for potential drug targets and biomarkers is a ongoing process in the field of genetics, and CHD4 is an attractive target due to its unique functions and the potential it holds for the development of new treatments for various diseases. In this article, we will discuss the biology of CHD4, its functions in the CRC, its potential as a drug target, and the current research in this field.

CHD4 was first identified in the CRC in 2005 by researchers led by Dr. David D. Moore at the University of California, San Diego. The CRC is a complex of proteins that work together to ensure the proper functioning of DNA in the cell. CHD4 was found to be a key component of the CRC, and it was shown to play a role in the regulation of DNA replication and repair.

CHD4 is a 21-kDa protein that contains a nucleotide-binding domain (NBD) and a helicase domain (HDB). The NBD is responsible for the physical interaction between CHD4 and DNA, while the HDB is responsible for the rotational motion of the DNA double helix. CHD4 has a unique structure that allows it to interact with specific DNA sequences. The protein has a distinct N-terminus that contains a single nucleotide, which is important for its ability to interact with DNA.

CHD4 is involved in the regulation of DNA replication and repair, which is critical for the development and maintenance of healthy cells. During DNA replication, CHD4 helps to ensure that the double helix is properly unwrapped and that each strand of DNA is properly copied. During repair, CHD4 helps to ensure that damaged DNA is repaired and that the cell is able to recover from the injury.

In addition to its role in DNA replication and repair, CHD4 has also been shown to play a role in the regulation of gene expression. CHD4 has been shown to interact with the protein p53, which is a well-known tumor suppressor gene. By interacting with p53, CHD4 has been shown to regulate the activity of p53, which is important for the regulation of cell growth and division.

The potential of CHD4 as a drug target is high due to its unique functions and the potential it holds for the development of new treatments for various diseases. One of the main advantages of CHD4 as a drug target is its specificity. CHD4 is a protein that is expressed in all cell types, making it an attractive target for drugs that can selectively target this protein.

Another advantage of CHD4 as a drug target is its role in the regulation of DNA replication and repair. CHD4 has been shown to play a critical role in the regulation of DNA replication and repair, which is critical for the development and maintenance of healthy cells. By targeting CHD4 with drugs that can inhibit its activity, researchers may be able to develop new treatments for various diseases, such as cancer, where DNA replication and repair are disrupted.

In addition to its potential as a drug target, CHD4 has also been shown to be a potential biomarker. The NBD and HDB domains of CHD4 have been shown to be differentially expressed in various cell types, which could be an attractive feature for biomarkers. By detecting changes in the expression of CHD4, researchers may be able to develop new

Protein Name: Chromodomain Helicase DNA Binding Protein 4

Functions: ATP-dependent helicase that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:17626165, PubMed:9804427, PubMed:16428440, PubMed:28977666). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity)

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