CHML: A Drug Target for Cancer Therapies (G1122)

Target Name: CHML

NCBI ID: G1122

CHML: A Drug Target for Cancer Therapies

CHML (CHromosome-associated molecular lead) is a drug target (also known as a biomarker) that is located on the CH28 region of chromosome 28 in the human genome. It is a gene that has been shown to be involved in a variety of cellular processes, including cell adhesion, migration, and the regulation of cell growth.

CHML is a gene that is expressed in many different tissues and organs in the human body, including the brain, pancreas, and gastrointestinal tract. It is also highly expressed in cancer cells, which makes it an attractive target for cancer therapies.

One of the key functions of CHML is its role in cell adhesion. CHML is involved in the formation of tight junctions, which are specialized junctions that form between cells and help to maintain tissue integrity. tight junctions are also involved in the regulation of ion and protein traffic in and out of cells, which is important for many cellular processes.

Another function of CHML is its role in cell migration. CHML is involved in the regulation of cell movement and in the development of migratory cancer cells. This is important because cancer cells are able to migrate to new tissues and organs and can establish new colonies, which can lead to the development of new tumors.

CHML is also involved in the regulation of cell growth. It helps to control the growth and division of cells, which is important for the development and maintenance of tissues and organs.

In addition to its role in cell adhesion, CHML is also involved in the regulation of many other cellular processes. It is involved in the production of cell surface antigens, which are proteins that are expressed on the surface of cells and can be recognized by other cells. It is also involved in the regulation of cytokine signaling, which is the production and regulation of proteins that play a role in immune responses.

CHML is a gene that has been shown to be involved in a variety of cellular processes, including cell adhesion, migration, and the regulation of cell growth. It is highly expressed in cancer cells, which makes it an attractive target for cancer therapies. Further research is needed to fully understand the role of CHML in human disease.

Protein Name: CHM Like Rab Escort Protein

Functions: Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family

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