Understanding CIAO2B: Potential Drug Target Or Biomarker for Neurological Disorders

Target Name: CIAO2B

NCBI ID: G51647

Understanding CIAO2B: Potential Drug Target Or Biomarker for Neurological Disorders

CIAO2B, also known as Cytosolic iron-sulfur assembly component 2B, is a protein that is expressed in various tissues throughout the body. It is a key player in the assembly of myelination Sheets, which are the basic building blocks of the nervous system. Myelination Sheets are responsible for transmitting electrical signals throughout the body, and they are crucial for the proper functioning of the nervous system.

Recent studies have identified CIAO2B as a potential drug target or biomarker for various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. This is because the abnormal accumulation of myelination Sheets, which is thought to be a hallmark of these disorders , is thought to be associated with the misfolding and mislocalization of CIAO2B.

One of the key factors that contribute to the misfolding and mislocalization of CIAO2B is its localization in the cytosol, which is the fluid inside the cells. The cytosol is known to be a dynamic environment that is constantly in motion, and it is thought to play a key role in the regulation of various cellular processes. However, the exact mechanisms by which CIAO2B is misfolded and mislocalized in the cytosol are not well understood.

One potential mechanism by which CIAO2B may be misfolded and mislocalized in the cytosol is its role in the formation of inclusion bodies, which are structures that can accumulate in the cytosol and disrupt the normal functions of the cells. Inclusion bodies are thought to be formed when the misfolded and disordered forms of a protein, such as CIAO2B, become aggregated in the cytosol and form a structure that can interact with and disrupt the normal functions of the cells.

Another potential mechanism by which CIAO2B may be misfolded and mislocalized in the cytosol is its role in the regulation of the cytosol environment. The cytosol is a constantly in motion environment that is subject to various chemical and physical stimuli, and it is thought to play a key role in the regulation of these stimuli. However, the exact mechanisms by which CIAO2B contributes to the regulation of the cytosol environment are not well understood.

In conclusion, CIAO2B is a protein that is expressed in various tissues throughout the body and is thought to play a key role in the assembly of myelination Sheets. Recent studies have identified CIAO2B as a potential drug target or biomarker for various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. This is because the abnormal accumulation of myelination Sheets, which is thought to be a hallmark of these disorders, is thought to be associated with the misfolding and mislocalization of CIAO2B. Further research is needed to better understand the exact mechanisms by which CIAO2B is misfolded and mislocalized in the cytosol, and to explore its potential as a drug target or biomarker.

Protein Name: Cytosolic Iron-sulfur Assembly Component 2B

Functions: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004, PubMed:22678362, PubMed:22678361, PubMed:29848660). As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins (PubMed:23891004, PubMed:29848660). As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633). Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis (PubMed:29848660)

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