CINP: A Protein Involved in Cell Signaling and Cellular Processes

Target Name: CINP

NCBI ID: G51550

CINP: A Protein Involved in Cell Signaling and Cellular Processes

CINP, or Cyclin-Dependent Kinase 2-Interacting Protein, is a protein that plays a crucial role in cell signaling pathways. It is a key component of the cyclin-dependent kinase (CDK)2 complex, which is a critical regulator of cell cycle progression and cell growth. CDK2 is a protein that consists of a catalytic domain and a regulatory domain, and it functions by activating or inhibiting the activity of several different proteins.

CINP is a 21-kDa protein that is expressed in a variety of tissues, including the brain, pancreas, and heart. It is primarily localized to the endoplasmic reticulum (ER), which is the body's primary site for protein synthesis and degradation. CINP is also known to be involved in the regulation of cellular processes such as cell adhesion, migration, and survival.

One of the key functions of CINP is its role in the regulation of the cell cycle. As a member of the CDK2 complex, CINP plays a critical role in the control of cell cycle progression and the timing of cell division. It is involved in the regulation of the G1/S transition, which is the stage of the cell cycle where the cell prepares for cell division. During the G1/S transition, CINP helps to ensure that the cell enters into the S phase of the cell cycle, where DNA replication and protein synthesis occur.

In addition to its role in cell cycle regulation, CINP is also involved in the regulation of several other cellular processes. For example, it has been shown to be involved in the regulation of cell adhesion, which is the process by which cells stick together and form tissues. CINP is also involved in the regulation of cell migration, which is the movement of cells through the body's various tissues. Additionally, CINP is has been shown to play a role in the regulation of cellular survival, as it has been shown to protect against various forms of cellular stress, such as radiation and chemotherapy.

Given its involvement in so many cellular processes, CINP is a promising drug target. Many studies have identified potential drug compounds that can inhibit the activity of CINP, and these compounds have been shown to have a variety of therapeutic effects, including the inhibition of cancer cell growth and the regulation of cellular processes that are involved in aging. In addition, CINP is also a potential biomarker, as its levels can be easily measured and its activity can be quantified.

Overall, CINP is a protein that plays a critical role in cell signaling pathways and is involved in the regulation of many cellular processes. Its potential as a drug target and biomarker makes it an attractive target for future research and development.

Protein Name: Cyclin Dependent Kinase 2 Interacting Protein

Functions: Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication (PubMed:16082200, PubMed:19889979). Regulates ATR-mediated checkpoint signaling in response to DNA damage (PubMed:19889979). Also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024). Promotes maturation of pre-60S ribosome together with SPATA5, SPATA5L1 and C1orf109 (PubMed:35354024)

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