Understanding CITATION2: A Potential Drug Target and Biomarker

Target Name: CITED2

NCBI ID: G10370

Understanding CITATION2: A Potential Drug Target and Biomarker

CITED2 (CITATION2_HUMAN), a protein encoded in the human gene CITATION2, is a potential drug target and biomarker associated with various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.

The CITATION2 gene is a member of the superfamily of core-protein-coding genes, which are characterized by the presence of a conserved core region and a variable region that includes several unique amino acid residues. The CITATION2 gene has a length of 215 amino acids and is localized to the cytoplasm of human cells.

CITATION2 is involved in various cellular processes, including cell adhesion, migration, and invasion. It plays a role in the regulation of actinin, a protein that is involved in cell-cell adhesion and in the regulation of cell migration. CITATION2 is also involved in the regulation of the cytoskeleton, which is responsible for the structure and movement of cells.

CITATION2 has been implicated in the development and progression of various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. For example, studies have shown that high levels of CITATION2 are associated with the development of pancreatic cancer, a type of cancer that is characterized by the formation of tumors in the pancreas, a gland located behind the stomach that produces hormones and digestive enzymes.

In addition to its involvement in cancer, CITATION2 has also been linked to the development of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells and the development of neurofibrillary tangles, which are thought to contribute to the symptoms of these disorders.

CITATION2 has also been implicated in the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. These conditions are characterized by the immune system attacking the body's own tissues, leading to inflammation and damage.

Despite the potential for CITATION2 as a drug target and biomarker, further research is needed to fully understand its role in these diseases. Studies are needed to determine the exact mechanism by which CITATION2 is involved in the development and progression of cancer, neurodegenerative disorders, and autoimmune diseases.

In addition, there are also studies that are focused on finding small molecule inhibitors of CITATION2 that can be used as potential drugs. These studies are being done to determine the effectiveness of these drugs in treating these diseases and to identify potential new treatments for these conditions.

Overall, CITATION2 is a protein that has the potential to be a drug target and biomarker for various diseases. Further research is needed to fully understand its role in these conditions and to develop effective treatments.

Protein Name: Cbp/p300 Interacting Transactivator With Glu/Asp Rich Carboxy-terminal Domain 2

Functions: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region

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