Exploring The Potential Treatments for Neurodegenerative Diseases

Target Name: CISH

NCBI ID: G1154

Exploring The Potential Treatments for Neurodegenerative Diseases

CISH (BACTS2) is a protein that is expressed in various tissues throughout the body, including the brain, spinal cord, and retina. It is a member of the BACTS2 family, which includes proteins that are involved in the immune response and inflammation.

One of the key functions of CISH is its role in the immune response. It is a core member of the T-cell receptor, which is responsible for recognizing and responding to foreign substances in the body. CISH helps to regulate the activity of T-cell receptor cells, allowing them to recognize and respond to different types of molecules.

In addition to its role in the immune response, CISH is also involved in the regulation of inflammation. It is a signaling molecule that is involved in the production of reactive oxygen species (ROS), which can cause damage to cells and contribute to the development of inflammation.

CISH has also been shown to be involved in the regulation of cell survival. It has been shown to play a role in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

CISH is also a potential drug target. Researchers have identified several small molecules that have been shown to interact with CISH and have the potential to be used as treatments for a variety of neurological conditions.

One of the small molecules that has been shown to interact with CISH is called BACTS2 inhibitor. This molecule has been shown to reduce the activity of CISH and protect against neurodegenerative diseases.

Another small molecule that has been shown to interact with CISH is called JNJ-752605. This molecule has been shown to inhibit the activity of CISH and protect against neurodegenerative diseases.

In addition to these small molecules, researchers are also exploring the use of other drugs as potential treatments for neurodegenerative diseases by targeting CISH.

Overall, CISH is a protein that is involved in a variety of important biological processes throughout the body. Its role in the immune response and inflammation, as well as its potential as a drug target, make it an attractive target for researchers to explore. Further research is needed to fully understand the role of CISH in neurodegenerative diseases and to develop effective treatments.

Protein Name: Cytokine Inducible SH2 Containing Protein

Functions: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity)

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