CHST6: A Protein Involved in Nervous System Function and Disease

Target Name: CHST6

NCBI ID: G4166

CHST6: A Protein Involved in Nervous System Function and Disease

CHST6 (C-GlcNAc6ST) is a protein that is expressed in various tissues of the human body, including the brain, spinal cord, and heart. It is a key player in the structure and function of the nervous system, and is involved in a wide range of physiological processes that are critical for human health.

One of the key functions of CHST6 is its role in the production and maintenance of the myelin sheath that surrounds and supports the neural cells in the brain and spinal cord. Myelin sheath is a specialized structure that helps to insulate and protect the neural cells, and is an essential part of the nervous system.

CHST6 is also involved in the regulation of the levels of neurotransmitters, such as dopamine and serotonin, in the brain and spinal cord. These neurotransmitters are responsible for transmitting signals between neurons and for maintaining the normal functioning of the nervous system.

In addition to its role in the nervous system, CHST6 is also involved in the regulation of various physiological processes that are critical for overall health. For example, it is involved in the production of hormones that help to regulate the growth and development of tissues, and it is also involved in the regulation of the blood pressure.

As a potential drug target, CHST6 is an attractive target for researchers because of its involvement in a wide range of important physiological processes. It is also relatively stable and has a relatively small size, which makes it an ideal candidate for small molecule inhibitors.

In addition to its potential as a drug target, CHST6 is also an attractive biomarker for a variety of neurological and psychiatric disorders. For example, CHST6 has been shown to be reduced in individuals with Alzheimer's disease, and may be a useful biomarker for this disease . It is also involved in the regulation of various psychiatric disorders, such as depression and anxiety, and may be a useful biomarker for these conditions as well.

Overall, CHST6 is a protein that is involved in a wide range of important physiological processes in the human body. As a potential drug target and biomarker, it is an attractive target for researchers who are looking to understand and treat a variety of neurological and psychiatric disorders.

Protein Name: Carbohydrate Sulfotransferase 6

Functions: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan (PubMed:11352640, PubMed:11278593, PubMed:12218059, PubMed:17690104). Cooperates with B4GALT4 galactosyltransferase and B3GNT7 N-acetylglucosaminyltransferase to construct and elongate the sulfated disaccharide unit [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer. Involved in biosynthesis of keratan sulfate in cornea, with an impact on proteoglycan fibril organization and corneal transparency (PubMed:17690104, PubMed:11278593, PubMed:12218059). Involved in sulfation of endothelial mucins such as GLYCAM1 (PubMed:11352640)

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