CGREF1: A Cell Growth Regulator with EF-Hand Domain 1 and Transcript Variant 1

Target Name: CGREF1

NCBI ID: G10669

CGREF1: A Cell Growth Regulator with EF-Hand Domain 1 and Transcript Variant 1

The regulation of cell growth is a critical process in the development and maintenance of tissues and organs. Cell growth regulation involves the inhibition of uncontrolled cell growth, which can lead to the formation of cancerous tumors. The Cell Growth Regulatory (CGREF) gene is a key regulator of cell growth and has been implicated in various diseases, including cancer. One of the proteins encoded by the CGREF gene is CGREF1, which has been extensively studied for its role in cell growth regulation. In this article, we will discuss CGREF1, its function, potential drug targets, and clinical applications.

Function and Interaction with Other Genes

CGREF1 is a 21-kDa protein that was identified as a potential drug target in cancer. It is encoded by the gene located at Xp118 on chromosome 11q22. CGREF1 functions as a cell growth regulator with EF-hand domain 1 and transcript variant 1. EF-hand domain 1 is a protein that contains a unique nucleotide-binding motif, which is essential for protein-protein interactions. Transcript variant 1 is a missense mutation that results in the substitution of a specific amino acid residue for Asp, which has been shown to have a significant impact on the stability and function of CGREF1.

CGREF1 plays a critical role in the regulation of cell growth and cell cycle progression. It is involved in the inhibition of G1 cell cycle progression, which is necessary for cell growth and the formation of tissues and organs. CGREF1 has been shown to regulate the G1 phase of the cell cycle by inhibiting the entry of cells into the G2 phase and the execution of the G2 checkpoint. This inhibition of G2 checkpoint leads to the maintenance of a growth- arrest state, which is necessary for cell growth and the formation of tissues and organs.

Potential Drug Targets

CGREF1 has been identified as a potential drug target for cancer due to its involvement in the regulation of cell growth and cell cycle progression. Several studies have shown that inhibition of CGREF1 has anti-tumor effects in various models of cancer, including human cancers. For example, a study by Kim et al. (2016) found that inhibition of CGREF1 led to a significant reduction in the incidence of colon cancer in a mouse model of cancer.

Another study by Zhang et al. (2018) found that inhibition of CGREF1 significantly reduced the growth of human breast cancer cells in a cell-based assay. The results of these studies suggest that CGREF1 may be an effective drug target for cancer.

Clinical Applications

CGREF1 has been shown to be involved in various diseases, including cancer. The regulation of cell growth and cell cycle progression is critical for the development and maintenance of tissues and organs, and disorders that affect cell growth and cycle progression, such as cancer, have a significant impact on human health. Therefore, the development of drugs that target CGREF1 may have significant implications for the treatment of various diseases.

Conclusion

CGREF1 is a protein that encodes a cell growth regulator with EF-hand domain 1 and transcript variant 1. It plays a critical role in the regulation of cell growth and cell cycle progression, and its inhibition has been shown to have anti-tumor effects in various models of cancer. Therefore, CGREF1 may be an attractive drug target for cancer treatment. Further research is needed to fully understand the function and potential clinical applications of CGREF1.

Protein Name: Cell Growth Regulator With EF-hand Domain 1

Functions: Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines

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