Exploring The Role of CCH Domains in Protein Structure and Function

Target Name: CHCHD2P9

NCBI ID: G645345

Other Name(s): Coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 | CHCHD9 | coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 | C9orf49

Exploring The Role of CCH Domains in Protein Structure and Function

Coiled-coil-helix-coiled-coil-helix (CCH) domains are a type of protein structure that are found in a variety of organisms, including humans. These domains are characterized by a specific arrangement of amino acids that give them their unique structure and function. CCH domains have been identified as potential drug targets or biomarkers due to their involvement in various cellular processes and their ability to interact with small molecules.

One of the key features of CCH domains is their ability to form helices, which can be either clockwise or counterclockwise. These helices play a crucial role in the regulation of various cellular processes, including cell division, gene expression, and signaling pathways. They are also involved in the formation of physical interactions between the domains, which can lead to the formation of complex structures.

One of the most interesting aspects of CCH domains is their ability to interact with small molecules, such as drugs or other molecules that are important for cellular processes. This interaction can lead to the formation of a stable complex, which can be targeted to specific cellular locations and can then influence the behavior of the cell.

One of the well-known examples of CCH domain containing proteins is the protein known as CHCHD2P9. This protein is a key regulator of the replication of DNA in the human genome. It is composed of four CCH domains and is located in the center of the nucleus.

The CHCHD2P9 protein plays a critical role in the regulation of DNA replication, particularly in the G1 phase of the cell cycle. During G1, the protein helps to ensure that the right amount of DNA is replicated in the cell, which is necessary for the formation of new chromosomes and for the proper functioning of the cell.

In addition to its role in DNA replication, the CHCHD2P9 protein has also been shown to play a key role in the regulation of gene expression. This is because of the CCH domains, which have been shown to interact with small molecules that are important for gene expression, such as RNA polymerase II. This interaction can lead to the formation of a stable complex, which can then influence the activity of the RNA polymerase II and the genes that it transcribes.

Furthermore, the CHCHD2P9 protein has also been shown to play a critical role in the regulation of cellular signaling pathways. This is because of its ability to form physical interactions with other proteins, such as the protein known as p53. This interaction can lead to the formation of a stable complex, which can then influence the activity of the p53 protein and the signaling pathways that it regulates.

In conclusion, the CHCHD2P9 protein is a fascinating example of a CCH domain containing protein. Its unique structure and function make it an attractive target for drug development and research into the regulation of cellular processes. Further studies are needed to fully understand the role of this protein in the regulation of DNA replication, gene expression, and cellular signaling pathways.

Protein Name: Coiled-coil-helix-coiled-coil-helix Domain Containing 2 Pseudogene 9

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