CFL1: A protein involved in multiple cellular processes and potential drug targets

Target Name: CFL1

NCBI ID: G1072

CFL1: A protein involved in multiple cellular processes and potential drug targets

CFL1 (Cofilin-1) is a protein that is expressed in various tissues throughout the body, including muscle, nerve, and heart. It is a member of the filament family, which includes proteins that are involved in the structure and function of microtubules, the cytoskeleton.

One of the unique features of CFL1 is its ability to interact with microtubules. It has been shown to play a role in the regulation of cell division and has been linked to the development and progression of various diseases, including cancer.

CFL1 has also been shown to be involved in the regulation of cell migration and has been linked to the development of neurodegenerative diseases. Additionally, it has been shown to play a role in the regulation of ion channels, which are important for the proper functioning of cells.

CFL1 has also been shown to be involved in the regulation of protein synthesis and has been linked to the development of diseases that are characterized by the overproduction of proteins.

CFL1 has also been shown to play a role in the regulation of gene expression and has been linked to the development of diseases that are characterized by the deregulation of gene expression.

In addition to its role in the regulation of microtubules and protein synthesis, CFL1 has also been shown to play a role in the regulation of cellular signaling pathways. It has been linked to the development of diseases that are characterized by the disruption of these pathways, including cancer.

CFL1 has also been shown to play a role in the regulation of cellular immune responses. It has been linked to the development of diseases that are characterized by the disruption of these responses, including autoimmune diseases.

In conclusion, CFL1 is a protein that has been shown to play a role in a wide range of cellular processes that are important for the proper functioning of cells. Its unique ability to interact with microtubules and its involvement in the regulation of cellular signaling pathways, immune responses, and protein synthesis make it an attractive drug target and potential biomarker for a variety of diseases. Further research is needed to fully understand the role of CFL1 in these processes and to develop effective treatments for the disorders associated with its dysfunction.

Protein Name: Cofilin 1

Functions: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:15580268). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (PubMed:21834987). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity)

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