CWC15: A Protein Regulating Splicing Efficiency and Gene Expression

Target Name: CWC15

NCBI ID: G51503

CWC15: A Protein Regulating Splicing Efficiency and Gene Expression

CWC15 (Cytosine-Western blotting 15) is a protein that is expressed in various cell types, including human brain, pancreatic, and liver cells. It is a component of the spliceosome, which is a protein complex that plays a crucial role in the process of gene expression. CWC15 has been shown to be involved in the regulation of splicing efficiency, which is the rate at which RNA splicing occurs from a single pre-mRNA transcript to a functional RNA molecule.

Drug targeting and biomarkers

CWC15 is a potential drug target because of its involvement in splicing regulation. Many diseases are caused by changes in gene expression, which can be caused by alterations in splicing efficiency. For example, alterations in splicing efficiency have been implicated in the development of certain diseases, such as cancer. Therefore, targeting CWC15 and modulating its activity could be a promising strategy for the development of new treatments for these diseases.

In addition to its potential as a drug target, CWC15 has also been identified as a potential biomarker for several diseases. The spliceosome is a protein complex that is involved in the regulation of gene expression, and changes in the spliceosome can be detected by using techniques such as Western blotting. Therefore, measuring the level of CWC15 in a patient's body could be a useful diagnostic tool for diseases that are caused by changes in the spliceosome. For example, if a patient has cancer, the level of CWC15 in their body may be increased compared to that of a healthy person. Therefore, measuring the level of CWC15 could be a promising biomarker for cancer diagnosis and monitoring.

Expression and regulation

CWC15 is a protein that is expressed in various cell types, including human brain, pancreatic, and liver cells. It is a component of the spliceosome, which is a protein complex that plays a crucial role in the process of gene expression. The spliceosome is composed of several subunits, including the protein SNF (Splicing factors Negative), which is responsible for recognizing the start of the pre-mRNA sequence, and the protein TAS, which is responsible for holding the pre-mRNA in place during splicing. CWC15 is located on the protein TAS and is in close proximity to the spliceosome's active site, which is where the TAS protein holds the pre-mRNA in place during splicing.

CWC15 is regulated by several factors, including the amount of cytosine in the precursor RNA, the strength of the splicing machinery, and the presence of tRNA. The amount of cytosine in the precursor RNA can affect the level of CWC15 in the body, as higher levels of cytosine are associated with lower levels of CWC15. The strength of the splicing machinery can also affect the level of CWC15, as stronger machines may result in increased levels of CWC15. The presence of tRNA can also affect the level of CWC15, as tRNA can bind to the spliceosome and modulate its activity.

Function and applications

CWC15 is involved in the regulation of splicing efficiency, which is the rate at which RNA splicing occurs from a single pre-mRNA transcript to a functional RNA molecule. It does this by interacting with the spliceosome's protein TAS and helping to hold the pre-mRNA in place during splicing. This interaction between CWC15 and TAS is critical for the efficient regulation of splicing efficiency.

In addition to its role in splicing regulation, CWC15 is also involved in the regulation of gene expression. It has been shown to interact with several transcription factors, including

Protein Name: CWC15 Spliceosome Associated Protein Homolog

Functions: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable)

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