SEPTIN4: A Potential Drug Target and Biomarker (G5414)

Target Name: SEPTIN4

NCBI ID: G5414

SEPTIN4: A Potential Drug Target and Biomarker

SEPTIN4 is a gene that encodes a protein known as Septin-4, which is a key component of the Septin system, a highly conserved protein complex that plays a critical role in cell division and cytoskeletal organization. The Septin system has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Therefore, targeting the Septin system has the potential to yield new therapeutic approaches for a variety of diseases.

SEPTIN4 has been identified as a potential drug target due to its involvement in several cellular processes that are associated with disease. One of the key functions of Septin-4 is its role in the formation of the cytoskeleton, which is the structure that organizes the cell's components during cell division and allows the cell to maintain its shape and stability. In cancer cells, the mis regulation of Septin-4 has been observed, leading to the formation of abnormal cell structures and the development of cancer. Therefore, targeting Sep

Protein Name: Septin 4

Functions: Filament-forming cytoskeletal GTPase (Probable). Pro-apoptotic protein involved in LGR5-positive intestinal stem cell and Paneth cell expansion in the intestines, via its interaction with XIAP (By similarity). May also play a role in the regulation of cell fate in the intestine (By similarity). Positive regulator of apoptosis involved in hematopoietic stem cell homeostasis; via its interaction with XIAP (By similarity). Negative regulator of repair and hair follicle regeneration in response to injury, due to inhibition of hair follicle stem cell proliferation, potentially via its interaction with XIAP (By similarity). Plays an important role in male fertility and sperm motility (By similarity). During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm (By similarity). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Required for dopaminergic metabolism in presynaptic autoreceptors; potentially via activity as a presynaptic scaffold protein (By similarity)

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