POU2F2: A Drug Target / Disease Biomarker (G5452)

Target Name: POU2F2

NCBI ID: G5452

POU2F2: A Drug Target / Disease Biomarker

POU2F2, also known asProtocollin-2-like 2, is a protein that is expressed in various tissues throughout the body. It is a member of the POU family of genes, which are known for their role in cell signaling and development. POU2F2 has been identified as a potential drug target and has been shown to play a role in a variety of biological processes, including cell proliferation, migration, and angiogenesis.

The POU2F2 gene was first identified in the late 1990s using transcriptional analysis of cDNA libraries from mouse tissue. It is located on chromosome 6 and has a predicted localization of 150 amino acids long. POU2F2 is a single gene that encodes a protein of 19 kilodalton (kDa), which is equivalent to approximately 21 amino acids per kDa.

The protein encoded by POU2F2 is a member of the POU family of genes, which are characterized by the presence of a specific domain called POU (polycystic ovary) domain. POU domains are a type of transmembrane domain that is characterized by the presence of a central transmembrane region and at least one extracellular loop. The POU2F2 protein has a single extracellular loop that is located at its C-terminus.

The POU2F2 protein is expressed in a variety of tissues throughout the body, including the brain, heart, muscle, liver, and blood vessels. It is also expressed in various cell types, including neurons, macrophages, and endothelial cells. POU2F2 is involved in a number of cellular processes that are important for normal development and function.

One of the key functions of POU2F2 is its role in cell signaling. POU2F2 has been shown to play a role in the regulation of cell proliferation and differentiation. For example, studies have shown that POU2F2 can inhibit the activity of the protein kinase inhibitor PDK4, which is involved in cell growth and survival. Additionally, POU2F2 has been shown to promote the activity of the transcription factor NF-kappa-B, which is involved in the regulation of inflammation and cellular signaling.

POU2F2 is also involved in the regulation of cell migration and angiogenesis. Studies have shown that POU2F2 can inhibit the activity of the protein serine kinase Pyk6, which is involved in cell migration and the formation of blood vessels. Additionally, POU2F2 has been shown to promote the activity of the transcription factor NF-kappa-B, which is involved in the regulation of angiogenesis and the formation of new blood vessels.

In addition to its role in cell signaling, POU2F2 has also been shown to play a role in the regulation of cellular processes that are important for normal development and function. For example, studies have shown that POU2F2 can promote the migration of neurons in the brain and that it is involved in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt over time.

Given its role in a variety of cellular processes, POU2F2 has been identified as a potential drug target. Studies have shown that POU2F2 can be targeted by small molecules, including inhibitors of the protein kinase PDK4 and inhibitors of the transcription factor NF-kappa-B. Additionally, POU2F2 has been shown to play a role in the regulation of cellular processes that are important for cancer development, and accordingly, it has been identified as a potential biomarker for cancer.

In conclusion, POU2F2 is a protein that is expressed in various tissues throughout the body and is involved in a variety of cellular processes that are important for normal development and function. Its role in cell signaling, cell migration, and angiogenesis makes it a potential drug target, and its involvement in the regulation of cellular processes that are important for cancer development makes it a potential biomarker

Protein Name: POU Class 2 Homeobox 2

Functions: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2904654, PubMed:7859290). Regulates IL6 expression in B cells with POU2AF1 (By similarity). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression (PubMed:2901913, PubMed:2904654). Modulates transcription transactivation by NR3C1, AR and PGR (PubMed:10480874)

More Common Targets