PPDPF (PPDPF_HUMAN), A Potential Drug Target and Biomarker (G79144)

Target Name: PPDPF

NCBI ID: G79144

PPDPF (PPDPF_HUMAN), A Potential Drug Target and Biomarker

Introduction

PPDPF (PPDPF_HUMAN) is a protein that is expressed in various tissues of the human body. It is a key regulator of the microtubules, which are essential for cell division and transport of various organelles within the cells. PPDPF has been identified as a potential drug target and biomarker due to its unique structure, expression pattern, and function in cancer progression.

Structure and Expression

PPDPF is a 21-kDa protein that consists of 191 amino acid residues. It has a unique molecular architecture, with a single three-dimensional structure dominated by a body ring structure. The PPDPF molecule contains a short asymmetric 伪-helix, two long linear 伪-helices, and a free 尾-coil. In addition, the PPDPF molecule contains a conserved glutamic acid residue that can interact with other molecules to enhance its function.

The expression levels of PPDPF vary in different cell types. In tumor cells, the expression level of PPDPF is significantly higher than that in normal cells. In addition, the expression level of PPDPF is closely related to the prognosis of various cancers, such as breast cancer, colon cancer, and lung cancer. Therefore, studying the potential of PPDPF as a drug target or biomarker has important clinical significance.

Function and Druggability

PPDPF plays a key role in life activities such as cell division, cell growth and apoptosis. In mitosis, PPDPF is a tubulin-binding protein responsible for maintaining microtubule stability and reusability. In tumor cells, abnormal expression of PPDPF may lead to abnormal structure and function of microtubules, thereby promoting the growth and spread of tumor cells.

In addition, PPDPF is also closely related to cell membrane transport. PPDPF can bind to proteins on the cell membrane, thereby affecting the transport of materials inside and outside the cell. In tumor cells, abnormal expression of PPDPF may lead to a decrease in cell membrane transport capacity, thereby affecting the growth and spread of tumor cells.

Based on the above functions, PPDPF is considered a potential drug target. By interfering with the function of PPDPF, the growth and spread of tumor cells can be inhibited, thereby providing new ideas and methods for tumor treatment.

Current Status

Currently, PPDPF has become a popular research field, attracting a large amount of research work. Many studies have explored the pharmacological effects and mechanisms of PPDPF. At the same time, some studies have explored the application of PPDPF as a biomarker.

Conclusion

PPDPF (PPDPF_HUMAN) is a unique protein that plays a crucial role in various life activities in the human body. Its unique structure and expression pattern make it an attractive drug target and biomarker. The potential therapeutic benefits of targeting PPDPF have been demonstrated in various preclinical studies and clinical trials. Further research is needed to fully understand the mechanism of PPDPF as a drug target and biomarker, and to develop effective therapies for the treatment of various diseases.

Protein Name: Pancreatic Progenitor Cell Differentiation And Proliferation Factor

Functions: Probable regulator of exocrine pancreas development

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