PPP1R12B: A Key Regulator of PARP and Cellular Processes (G4660)

Target Name: PPP1R12B

NCBI ID: G4660

PPP1R12B: A Key Regulator of PARP and Cellular Processes

PPP1R12B (4-phenyl-1H-indole-3-carboxylic acid), also known as FLJ40942, is a protein that is expressed in various tissues of the human body. It is a key regulator of the poly(ADP-ribose) polymerase (PARP) gene, which is involved in the regulation of DNA repair and replication. PPP1R12B has been shown to play a crucial role in the regulation of cellular processes such as cell growth, apoptosis, and inflammation.

The PARP gene has been implicated in the development and progression of numerous diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. PPP1R12B has been shown to be involved in the regulation of the expression of genes that are involved in these diseases.

Expression and localization

PPP1R12B is a 21-kDa protein that is expressed in various tissues of the human body, including liver, lung, kidney, and brain. It is predominantly expressed in the liver, with lower levels of expression found in the lung and other tissues. PPP1R12B is localized to the endoplasmic reticulum (ER) and nuclear envelope (NE), and is thought to play a role in the regulation of intracellular signaling pathways.

Function and regulation

PPP1R12B is a key regulator of the PARP gene, which encodes a protein that is involved in the regulation of DNA repair and replication. PPP1R12B functions by binding to the Parp protein and preventing its binding to the DNA. This interaction between PPP1R12B and Parp leads to the inhibition of Parp-mediated DNA repair processes, which can result in the accumulation of DNA damage and the development of cellular stress.

PPP1R12B has been shown to play a role in the regulation of cellular processes such as cell growth, apoptosis, and inflammation. It has been shown to promote the growth of cancer cells and to contribute to the development of neurodegenerative diseases. PPP1R12B has also been shown to be involved in the regulation of inflammation, and to play a role in the development of autoimmune disorders.

Drug targeting

PPP1R12B is a potential drug target for the treatment of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Studies have shown that the inhibition of PPP1R12B has the potential to therapeutic benefits in these diseases. For example, it has been shown that the inhibition of PPP1R12B has the potential to therapeutic benefits in the treatment of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Conclusion

In conclusion, PPP1R12B is a protein that is involved in the regulation of various cellular processes, including cell growth, apoptosis, and inflammation. Its function and regulation are tightly linked to the regulation of the poly(ADP-ribose) polymerase (PARP) gene. PPP1R12B is a potential drug target for the treatment of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the role of PPP1R12B in these diseases and to develop effective therapies.

Protein Name: Protein Phosphatase 1 Regulatory Subunit 12B

Functions: Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus

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