PPP1R3E: A Potential Drug Target and Biomarker (G90673)

Target Name: PPP1R3E

NCBI ID: G90673

Other Name(s): PPR3E_HUMAN | Protein phosphatase 1 regulatory subunit 3E | protein phosphatase 1, regulatory (inhibitor) subunit 3E | protein phosphatase 1 regulatory subunit 3E | Protein phosphatase 1, regulatory (inhibitor) subunit 3E

PPP1R3E: A Potential Drug Target and Biomarker

PPP1R3E (PPR3E_HUMAN), a protein located in the endoplasmic reticulum (ER), has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and metabolic diseases. Its functions and interactions with other proteins have been extensively studied, providing a strong foundation for its potential as a drug target.

The endoplasmic reticulum (ER) is a major site of protein modification and transport within membrane-enclosed cells. There are many different proteins on the ER membrane that are responsible for modifying, transporting, and excreting proteins. PPP1R3E is a protein on the ER membrane and consists of two major subunits: N-terminal 伪-helix, mid-range 尾-curl, and C-terminal domain.

PPP1R3E plays multiple important biological functions in cells. It is responsible for modifying and transporting proteins within cells, including some important metabolic enzymes. For example, PPP1R3E modifies and transports the insulin A intracellular enzyme, which is an important target for diabetes treatment. PPP1R3E is also involved in apoptosis, an important form of cell death that is critical for maintaining tissue and organ homeostasis.

PPP1R3E is also an important inflammatory molecule. Studies have shown that PPP1R3E can regulate inflammatory responses in immune cells and has potential application value in the treatment of inflammatory diseases. In addition, PPP1R3E is also closely related to neuronal death and synaptic plasticity. It plays a key role in neuronal aging and synaptic plasticity and is therefore relevant for the treatment of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

As a protein, PPP1R3E has a variety of potential drug targets. For example, researchers have discovered that PPP1R3E is a potent substrate of PD-L1, a key molecule in immune cells that is associated with tumor immune evasion. In addition, PPP1R3E can also serve as a potential biomarker for metabolic syndrome, a disease associated with obesity, diabetes, and cardiovascular disease.

PPP1R3E, as a protein, has multiple biological functions and interactions. Its functions and interactions make it a potential drug target. Through drug intervention targeting PPP1R3E, a variety of diseases can be treated, including cancer, neurodegenerative diseases, and metabolic diseases. Future research will further study the biological functions and drug targets of PPP1R3E to provide new ideas and strategies for the treatment of these diseases.

Protein Name: Protein Phosphatase 1 Regulatory Subunit 3E

Functions: Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis

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