PPI2R2A: Key Regulator of Renin-Angiotensin-Aldosterone System

Target Name: PPP2R2A

NCBI ID: G5520

Other Name(s): 2ABA_HUMAN | FLJ26613 | B55ALPHA | PR55alpha | Protein phosphatase 2 regulatory subunit Balpha, transcript variant 2 | protein phosphatase 2 (formerly 2A), regulatory subunit B (PR52), alpha isoform | MGC52248 | PP2A subunit B isoform B55-alpha | PR52A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (isoform 2) | PP2A subunit B isoform alpha | PP2A subunit B isoform PR55-alpha | PR55A | PP2A subunit B isoform R2-alpha | serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | PPP2R2A variant 2 | Protein phosphatase 2 (formerly 2A), regulatory subunit B (PR52), alpha isoform | protein phosphatase 2 regulatory subunit Balpha | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (isoform 1) | FLJ41727 | protein phosphatase 2, regulatory subunit B, alpha | PPP2R2A variant 1 | Protein phosphatase 2 regulatory subunit Balpha, transcript variant 1 | serine/threonine protein phosphatase 2A, 55 KDA regulatory subunit B, alpha isoform | B55A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | Serine/threonine protein phosphatase 2A, 55 KDA regulatory subunit B, alpha isoform | DKFZp686N05117

PPI2R2A: Key Regulator of Renin-Angiotensin-Aldosterone System

PPI2R2A (2ABA_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, heart, and kidneys. The protein is made up of 284 amino acids and has a calculated molecular weight of 35.1 kDa. It is a key regulator of the renin-angiotensin-aldosterone system (RAAS), which plays a crucial role in maintaining blood pressure and maintaining proper fluid balance in the body.

The RAAS is a complex system that is responsible for regulating various physiological processes in the body, including blood pressure, blood volume, and electrolyte balance. The RAAS is activated when the body perceives a threat, such as the presence of stress or inflammation, and helps to maintain these processes at a stable level.

One of the key proteins that is involved in the RAAS is PPI2R2A. This protein is a key regulator of the RAAS and helps to maintain the balance between the activity of the RAAS and the regulation of angiotensin II, a hormone that causes blood pressure to rise.

The PPI2R2A protein is expressed in various tissues of the body, including the brain, heart, and kidneys, and is involved in the regulation of various physiological processes in these tissues. It is a key regulator of the RAAS and helps to maintain the balance between the activity of the RAAS and the regulation of angiotensin II.

The Importance of PPI2R2A

PPI2R2A is a critical protein that helps to maintain the balance between the activity of the RAAS and the regulation of angiotensin II. The RAAS is responsible for maintaining the blood pressure and maintaining proper fluid balance in the body, and angiotensin II is a hormone that causes blood pressure to rise.

PPI2R2A helps to regulate the activity of the RAAS by helping to maintain the balance between the activity of the protein and the regulation of angiotensin II. This helps to maintain the proper functioning of the body and keeps the blood pressure at a stable level.

PPI2R2A is also involved in the regulation of various physiological processes in the brain, heart, and kidneys. It is a key regulator of the renin-angiotensin-aldosterone system (RAAS), which plays a crucial role in maintaining blood pressure and maintaining proper fluid balance in the body.

The Potential Applications of PPI2R2A

PPI2R2A is a drug target and has the potential to be used in the treatment of various diseases. The RAAS is a complex system that is involved in many physiological processes in the body, and PPI2R2A is a key regulator of this system.

As a result, PPI2R2A has the potential to be used in the treatment of various diseases that are related to the RAAS. These diseases include heart failure, hypertension, and diabetes.

PPI2R2A is also a biomarker that can be used to diagnose and monitor various diseases. For example, PPI2R2A levels can be used to diagnose heart failure, and changes in PPI2R2A levels can be used to monitor the effectiveness of various treatments for heart failure.

Conclusion

PPI2R2A (2ABA_HUMAN) is a protein that is involved in the regulation of various physiological processes in the body. It is a key regulator of the renin-angiotensin-aldosterone system (RAAS) and helps to maintain the balance between the activity of the RAAS and the regulation of angiotensin II.

PPI2R2A has the potential to be used in the treatment of various diseases that are related to the RAAS. It is also a biomarker that can be used to diagnose and monitor various diseases.

Protein Name: Protein Phosphatase 2 Regulatory Subunit Balpha

Functions: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758)

More Common Targets